Gene

prpf8

ID
ZDB-GENE-030131-577
Name
pre-mRNA processing factor 8
Symbol
prpf8 Nomenclature History
Previous Names
  • id:ibd1257
  • ik:tdsubc_2a9 (1)
  • im:7141966 (1)
  • tdsubc_2a9
  • wu:fb37c02
  • wu:fb73e06
  • xx:tdsubc_2a9
  • zgc:56504
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have pre-mRNA intronic binding activity and snRNA binding activity. Involved in spliceosomal tri-snRNP complex assembly. Predicted to localize to U5 snRNP and catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 13. Is expressed in brain. Orthologous to human PRPF8 (pre-mRNA processing factor 8).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Keightley et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prpf8 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
retinitis pigmentosa 13 Alliance Retinitis pigmentosa 13 600059
Associated With prpf8 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000555 JAB1/MPN/MOV34 metalloenzyme domain
Domain IPR012591 PRO8NT domain
Domain IPR012592 PROCN domain
Domain IPR012984 PROCT domain
Domain IPR019580 Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding
Domain IPR019581 Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding
Domain IPR019582 RNA recognition motif, spliceosomal PrP8
Domain IPR021983 PRP8 domain IV core
Domain IPR037518 MPN domain
Family IPR027652 Pre-mRNA-processing-splicing factor 8
Homologous_superfamily IPR012337 Ribonuclease H-like superfamily
Homologous_superfamily IPR042516 Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily
Homologous_superfamily IPR043172 Prp8 RNase domain IV, palm region
Homologous_superfamily IPR043173 Prp8 RNase domain IV, fingers region
Domain Details Per Protein
Protein Length JAB1/MPN/MOV34 metalloenzyme domain MPN domain Pre-mRNA-processing-splicing factor 8 Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding PRO8NT domain PROCN domain PROCT domain PRP8 domain IV core Prp8 RNase domain IV, fingers region Prp8 RNase domain IV, palm region Ribonuclease H-like superfamily RNA recognition motif, spliceosomal PrP8
UniProtKB:A0A8M2B4I2 2342
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations