Gene

eif2s3

ID
ZDB-GENE-030131-5552
Name
eukaryotic translation initiation factor 2, subunit 3 gamma
Symbol
eif2s3 Nomenclature History
Previous Names
  • eukaryotic translation initiation factor 2 gamma (1)
  • fi03g03
  • wu:fi03g03
  • wu:fi37d04
  • zgc:63805
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to contribute to tRNA binding activity. Predicted to be involved in formation of translation preinitiation complex and positive regulation of translational fidelity. Predicted to localize to cytosol and eukaryotic translation initiation factor 2 complex. Human ortholog(s) of this gene implicated in MEHMO syndrome. Orthologous to several human genes including EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With eif2s3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
MEHMO syndrome Alliance MEHMO syndrome 300148
Associated With eif2s3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000795 Translational (tr)-type GTP-binding domain
Domain IPR004161 Translation elongation factor EFTu-like, domain 2
Domain IPR015256 Initiation factor eIF2 gamma, C-terminal
Domain IPR044127 Initiation factor eIF2 gamma, domain 2
Domain IPR044128 Initiation factor eIF2 gamma, GTP-binding domain
Homologous_superfamily IPR009000 Translation protein, beta-barrel domain superfamily
Homologous_superfamily IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length Initiation factor eIF2 gamma, C-terminal Initiation factor eIF2 gamma, domain 2 Initiation factor eIF2 gamma, GTP-binding domain P-loop containing nucleoside triphosphate hydrolase Translational (tr)-type GTP-binding domain Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal Translation elongation factor EFTu-like, domain 2 Translation protein, beta-barrel domain superfamily
UniProtKB:E9QBU9 258
UniProtKB:F1RBM8 279
UniProtKB:F1QGW6 472
UniProtKB:Q7SXT9 472
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations