Gene

cbx2

ID
ZDB-GENE-030131-5502
Name
chromobox homolog 2 (Drosophila Pc class)
Symbol
cbx2 Nomenclature History
Previous Names
  • pc1 (1)
  • wu:fd20e09
  • zgc:103563
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of PRC1 complex. Predicted to be active in heterochromatin. Is expressed in several structures, including digestive system; heart; nervous system; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in 46,XY sex reversal 5. Orthologous to human CBX2 (chromobox 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa13655Allele with one point mutationUnknownPremature StopENU
1 - 1 of 1
Show
Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-cbx2N/AHuang et al., 2013
1 - 1 of 1
Show
Human Disease
Associated With cbx2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
46,XY sex reversal 5 Alliance ?46XY sex reversal 5 613080
1 - 1 of 1
Associated With cbx2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023779 Chromo domain, conserved site
Conserved_site IPR033773 CBX family C-terminal motif
Domain IPR000953 Chromo/chromo shadow domain
Domain IPR023780 Chromo domain
Family IPR042796 Chromobox protein homolog 2
1 - 5 of 6 Show all
Domain Details Per Protein
Protein Additional Resources Length CBX family C-terminal motif Chromobox protein homolog 2 Chromo/chromo shadow domain Chromo domain Chromo domain, conserved site Chromo-like domain superfamily
UniProtKB:Q8JIQ9 InterPro 510
UniProtKB:A0A8N7UZW1 InterPro 510
1 - 2 of 2
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 3
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA cbx2-201 (1) Ensembl 2,141 nt
ncRNA cbx2-002 (1) Ensembl 853 nt
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-261G11ZFIN Curated Data
Contained inBACCH211-253B18ZFIN Curated Data
EncodesESTfd20e09
EncodescDNAMGC:103563ZFIN Curated Data
EncodescDNAMGC:192035ZFIN Curated Data
1 - 5 of 5
Show
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanCBX217
Amino acid sequence comparison (1)
MouseCbx211
Amino acid sequence comparison (1)
Citations
1 - 8 of 8
Show