cbx2

ID

ZDB-GENE-030131-5502

Name

chromobox homolog 2 (Drosophila Pc class)

Symbol

cbx2 Nomenclature History

Previous Names

pc1 (1)
wu:fd20e09
zgc:103563

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable methylated histone binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be part of PRC1 complex. Predicted to be active in heterochromatin. Is expressed in several structures, including digestive system; heart; nervous system; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in 46,XY sex reversal 5. Orthologous to human CBX2 (chromobox 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:103563 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cbx2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
46,XY sex reversal 5	Alliance	?46XY sex reversal 5	613080

Associated With cbx2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023779	Chromo domain, conserved site
Conserved_site	IPR033773	CBX family C-terminal motif
Domain	IPR000953	Chromo/chromo shadow domain
Domain	IPR023780	Chromo domain
Family	IPR042796	Chromobox protein homolog 2
Homologous_superfamily	IPR016197	Chromo-like domain superfamily