ZFIN is now using GRCz12tu for Genomic Data
Gene
top1b
- ID
- ZDB-GENE-030131-5390
- Name
- DNA topoisomerase Ib
- Symbol
- top1b Nomenclature History
- Previous Names
-
- top1
- fd15f07
- wu:fd15f07
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to be involved in DNA replication; DNA topological change; and chromosome segregation. Predicted to act upstream of or within rhythmic process. Predicted to be located in nucleus. Predicted to be active in nucleolus. Orthologous to human TOP1 (DNA topoisomerase I).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-top1b | Thomas et al., 2024 | |
| CRISPR2-top1b | Thomas et al., 2024 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| DNA topoisomerase I, camptothecin-resistant |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR008336 | DNA topoisomerase I, DNA binding, eukaryotic-type |
| Domain | IPR013499 | DNA topoisomerase I, eukaryotic-type |
| Domain | IPR013500 | DNA topoisomerase I, catalytic core, eukaryotic-type |
| Domain | IPR025834 | Topoisomerase I C-terminal domain |
| Domain | IPR048045 | DNA topoisomerase I, DNA-binding domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | DNA breaking-rejoining enzyme, catalytic core | DNA topoisomerase I | DNA topoisomerase IB | DNA topoisomerase I, catalytic core, alpha/beta subdomain | DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type | DNA topoisomerase I, catalytic core, eukaryotic-type | DNA topoisomerase I, DNA-binding domain | DNA topoisomerase I, DNA binding, eukaryotic-type | DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily | DNA topoisomerase I, DNA binding, N-terminal domain 1 | DNA topoisomerase I, DNA binding, N-terminal domain 2 | DNA topoisomerase I, eukaryotic-type | Topoisomerase I C-terminal domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1RL46 | InterPro | 751 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-85D8 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-213L17 | ZFIN Curated Data | |
| Contains | SNP | rs3729226 | ZFIN Curated Data | |
| Contains | SNP | rs3729227 | ZFIN Curated Data | |
| Encodes | EST | fd15f07 |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_002666402 (1) | GRCz12tu | 5170 nt | |
| Genomic | GenBank:CU633907 (1) | 38805 nt | ||
| Polypeptide | UniProtKB:A0A8M1RL46 (1) | 751 aa |
- Thomas, R.C., Zaksauskaite, R., Al-Kandari, N.Y., Hyde, A.C., Abugable, A.A., El-Khamisy, S.F., van Eeden, F.J. (2024) Second generation lethality in RNAseH2a knockout zebrafish. Nucleic acids research. 52(18):11014-11028
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Nachtigall, P., Dias, M., Pinhal, D. (2014) Evolution and genomic organization of muscle microRNAs in fish genomes. BMC Evolutionary Biology. 14:196
- Smith, S.F., Snell, P., Gruetzner, F., Bench, A.J., Haaf, T., Metcalfe, J.A., Green, A.R., and Elgar, G. (2002) Analyses of the extent of shared synteny and conserved gene orders between the genome of Fugu rubripes and human 20q. Genome research. 12(5):776-784
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