ZFIN is now using GRCz12tu for Genomic Data
Gene
cox5ab
- ID
- ZDB-GENE-030131-5162
- Name
- cytochrome c oxidase subunit 5Ab
- Symbol
- cox5ab Nomenclature History
- Previous Names
-
- Cox5a2 (1)
- cox5a
- cb01f09
- mg:cb01f09
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables cytochrome-c oxidase activity. Acts upstream of or within embryonic organ development and spinal cord motor neuron differentiation. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Is expressed in brain; gill; heart; liver; and skeletal muscle. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 20. Orthologous to human COX5A (cytochrome c oxidase subunit 5A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Baden et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa43022 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mitochondrial complex IV deficiency nuclear type 20 | Alliance | Mitochondrial complex IV deficiency, nuclear type 20 | 619064 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome c oxidase, subunit Va/VI | Cytochrome c oxidase, subunit Va/VI superfamily |
|---|---|---|---|---|
| UniProtKB:A0A0R4IVC8 | InterPro | 138 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cox5ab-201
(1)
|
Ensembl | 673 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001305577 (1) | 673 nt | ||
| Genomic | GenBank:JBMGRA010000018 (1) | |||
| Polypeptide | UniProtKB:A0A0R4IVC8 (1) | 138 aa |
- Rostad, K.O., Trognitz, T., Frøyset, A.K., Bifulco, E., Fladmark, K.E. (2024) Accelerated Sarcopenia Phenotype in the DJ-1/Park7-Knockout Zebrafish. Antioxidants (Basel, Switzerland). 13(12):
- Lin, H., Lin, F., Yuan, J., Cui, F., Chen, J. (2021) Toxic effects and potential mechanisms of Fluxapyroxad to zebrafish (Danio rerio) embryos. The Science of the total environment. 769:144519
- Yang, Y., Dong, F., Liu, X., Xu, J., Wu, X., Zheng, Y. (2020) Thifluzamide induces the toxic effects on zebrafish (Danio rerio) via inhibition of succinate dehydrogenase (SDH). Environmental pollution (Barking, Essex : 1987). 265:115031
- Zhuang, J., Pan, Z.J., Mengqiu-Li, ., Hong, F.S., Zhu, C.K., Wu, N., Chang, G., Wang, H., Zhao, X.X. (2020) BDE-47 induced apoptosis in zebrafish embryos through mitochondrial ROS-mediated JNK signaling. Chemosphere. 258:127385
- Munro, B., Horvath, R., Müller, J.S. (2018) Nucleoside supplementation modulates mitochondrial DNA copy number in the dguok-/- zebrafish. Human molecular genetics. 28(5):796-803
- Piragyte, I., Clapes, T., Polyzou, A., Klein Geltink, R.I., Lefkopoulos, S., Yin, N., Cauchy, P., Curtis, J.D., Klaeylé, L., Langa, X., Beckmann, C.C.A., Wlodarski, M.W., Müller, P., Van Essen, D., Rambold, A., Kapp, F.G., Mione, M., Buescher, J.M., Pearce, E.L., Polyzos, A., Trompouki, E. (2018) A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways. Nature communications. 9:3090
- Yang, Y., Liu, W., Li, D., Qian, L., Fu, B., Wang, C. (2017) Altered glycometabolism in zebrafish exposed to thifluzamide. Chemosphere. 183:89-96
- Chen, W.C., Wang, Z., Missinato, M.A., Park, D.W., Long, D.W., Liu, H.J., Zeng, X., Yates, N.A., Kim, K., Wang, Y. (2016) Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration. Science advances. 2:e1600844
- Yang, Y., Liu, W., Mu, X., Qi, S., Fu, B., Wang, C. (2016) Biological response of zebrafish embryos after short-term exposure to thifluzamide. Scientific Reports. 6:38485
- Artuso, L., Romano, A., Verri, T., Domenichini, A., Argenton, F., Santorelli, F.M., and Petruzzella, V. (2012) Mitochondrial DNA metabolism in early development of zebrafish (Danio rerio). Biochim. Biophys. Acta Bio-Energetics. 1817(7):1002-1011
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