ZFIN is now using GRCz12tu for Genomic Data
Gene
pagr1
- ID
- ZDB-GENE-030131-4801
- Name
- PAXIP1 associated glutamate-rich protein 1
- Symbol
- pagr1 Nomenclature History
- Previous Names
-
- c16orf53 (1)
- wu:fd61a05
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable nuclear estrogen receptor binding activity. Acts upstream of or within brain development. Predicted to be part of MLL3/4 complex. Is expressed in brain. Orthologous to human PAGR1 (PAXIP1 associated glutamate rich protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Blaker-Lee et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Blaker-Lee et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR028213 | PTIP-associated protein 1 |
1 - 1 of 1
Domain Details Per Protein
| Protein | Additional Resources | Length | PTIP-associated protein 1 |
|---|---|---|---|
| UniProtKB:E7F1D2 | InterPro | 273 | |
| UniProtKB:A0A8M9PW39 | InterPro | 214 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-166G5 | ZFIN Curated Data | |
| Encodes | EST | fd61a05 |
1 - 2 of 2
Show
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001326689 (1) | 1202 nt | ||
| Genomic | GenBank:CR762399 (1) | 121539 nt | ||
| Polypeptide | UniProtKB:E7F1D2 (1) | 273 aa |
- McCammon, J.M., Blaker-Lee, A., Chen, X., Sive, H. (2017) The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes. Human molecular genetics. 26:3699-3712
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Blaker-Lee, A., Gupta, S., McCammon, J.M., De Rienzo, G., and Sive, H. (2012) Zebrafish homologs of 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes. Disease models & mechanisms. 5(6):834-851
1 - 3 of 3
Show