Gene
nr5a5
- ID
- ZDB-GENE-030131-4652
- Name
- nuclear receptor subfamily 5, group A, member 5
- Symbol
- nr5a5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables DNA binding activity and DNA-binding transcription factor activity. Predicted to be involved in hormone-mediated signaling pathway; regulation of transcription by RNA polymerase II; and tissue development. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including digestive system; fin; gill; heart; and pleuroperitoneal region. Orthologous to human NR5A2 (nuclear receptor subfamily 5 group A member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- af327373 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR016355 | Nuclear hormone receptor family 5-like |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Nuclear hormone receptor | Nuclear hormone receptor family 5-like | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QKV6 | InterPro | 511 | ||||||
| UniProtKB:B3DKN2 | InterPro | 537 | ||||||
| UniProtKB:A0AB32TI31 | InterPro | 451 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-39A12 | ZFIN Curated Data | |
| Encodes | EST | af327373 | Bertrand et al., 2007 | |
| Encodes | EST | fd46g06 | ||
| Encodes | cDNA | MGC:111842 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153866 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195336 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_214779 (1) | 2086 nt | ||
| Genomic | GenBank:CR933758 (1) | 188461 nt | ||
| Polypeptide | UniProtKB:B3DKN2 (1) | 537 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | NR5A2 | 1 | Amino acid sequence comparison (1) |
- Yang, Y.J., Wang, Y., Li, Z., Zhou, L., Gui, J.F. (2017) Sequential, Divergent, and Cooperative Requirements of Foxl2a and Foxl2b in Ovary Development and Maintenance of Zebrafish.. Genetics. 205(4):1551-1572
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zhao, Y., Zhang, K., Giesy, J.P., Hu, J. (2015) Families of Nuclear Receptors in Vertebrate Models: Characteristic and Comparative Toxicological Perspective. Scientific Reports. 5:8554
- Long, Y., Song, G., Yan, J., He, X., Li, Q., and Cui, Z. (2013) Transcriptomic characterization of cold acclimation in larval zebrafish. BMC Genomics. 14(1):612
- Sun, D., Zhang, Y., Wang, C., Hua, X., Zhang, X.A., and Yan, J. (2013) Sox9-related signaling controls zebrafish juvenile ovary-testis transformation. Cell Death & Disease. 4:e930
- Long, Y., Li, L., Li, Q., He, X., and Cui, Z. (2012) Transcriptomic characterization of temperature stress responses in larval zebrafish. PLoS One. 7(5):e37209
- Koskinen, J., Karlsson, J., and Olsson, P.E. (2009) Sox9a regulation of ff1a in zebrafish (Danio rerio) suggests an involvement of ff1a in cartilage development. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 153(1):39-43
- Sreenivasan, R., Cai, M., Bartfai, R., Wang, X., Christoffels, A., and Orban, L. (2008) Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. PLoS One. 3(3):e1791
- Bertrand, S., Thisse, B., Tavares, R., Sachs, L., Chaumot, A., Bardet, P.L., Escrivà, H., Duffraisse, M., Marchand, O., Safi, R., Thisse, C., and Laudet, V. (2007) Unexpected Novel Relational Links Uncovered by Extensive Developmental Profiling of Nuclear Receptor Expression. PLoS Genetics. 3(11):e188
- Kuo, M.W., Postlethwait, J., Lee, W.C., Lou, S.W., Chan, W.K., and Chung, B.C. (2005) Gene duplication, gene loss and evolution of expression domains in the vertebrate nuclear receptor NR5A (Ftz-F1) family. The Biochemical journal. 389(Pt 1):19-26
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