ZFIN is now using GRCz12tu for Genomic Data
Gene
nckap1
- ID
- ZDB-GENE-030131-4426
- Name
- NCK-associated protein 1
- Symbol
- nckap1 Nomenclature History
- Previous Names
-
- si:dkey-234n3.1
- wu:fd05c01 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Acts upstream of or within heart development and neuron projection morphogenesis. Predicted to be located in lamellipodium membrane. Predicted to be part of SCAR complex. Orthologous to human NCKAP1 (NCK associated protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027013Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa11335 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30927 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34756 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41545 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44713 | Allele with one point mutation | Unknown | Unknown | ENU | |
| uab401 | Allele with one delins | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISRP1-nckap1 | Edwards et al., 2020 | |
| MO1-nckap1 | N/A | Biswas et al., 2014 |
| MO2-nckap1 | N/A | Biswas et al., 2014 |
| MO3-nckap1 | N/A | Biswas et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR019137 | Nck-associated protein 1 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Nck-associated protein 1 |
|---|---|---|---|
| UniProtKB:B0S6R1 | InterPro | ||
| UniProtKB:A0A2R8QPW3 | InterPro | 1134 | |
| UniProtKB:A0A8M2BFE2 | InterPro | 1132 | |
| UniProtKB:A0A2U3TVM3 | InterPro | 1124 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nckap1-201
(1)
|
Ensembl | 4,510 nt | ||
| mRNA |
nckap1-202
(1)
|
Ensembl | 4,386 nt | ||
| mRNA |
nckap1-203
(1)
|
Ensembl | 920 nt | ||
| mRNA |
nckap1-204
(1)
|
Ensembl | 4,018 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-234N3 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-237J22 | ZFIN Curated Data | |
| Contains | SNP | rs3728241 | ZFIN Curated Data | |
| Contains | SNP | rs3728242 | ZFIN Curated Data | |
| Encodes | EST | fd05c01 |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001137665 (1) | 4510 nt | ||
| Genomic | GenBank:CR513785 (1) | 141682 nt | ||
| Polypeptide | UniProtKB:A0A2R8QPW3 (1) | 1134 aa |
- Edwards, J.J., Rouillard, A.D., Fernandez, N.F., Wang, Z., Lachmann, A., Shankaran, S.S., Bisgrove, B.W., Demarest, B., Turan, N., Srivastava, D., Bernstein, D., Deanfield, J., Giardini, A., Porter, G., Kim, R., Roberts, A.E., Newburger, J.W., Goldmuntz, E., Brueckner, M., Lifton, R.P., Seidman, C.E., Chung, W.K., Tristani-Firouzi, M., Yost, H.J., Ma'ayan, A., Gelb, B.D. (2020) Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. JACC. Basic to translational science. 5:376-386
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Wang, X., Zheng, Y., Zhang, Y., Li, J., Zhang, H., Wang, H. (2016) Effects of β-diketone antibiotic mixtures on behavior of zebrafish (Danio rerio). Chemosphere. 144:2195-2205
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Biswas, S., Duy, P.Q., Hao le, T., Beattie, C.E., and Jontes, J.D. (2014) Protocadherin-18b interacts with Nap1 to control motor axon growth and arborization in zebrafish. Molecular biology of the cell. 25(5):633-42
- Riera, M., Burguera, D., Garcia-Fernàndez, J., and Gonzàlez-Duarte, R. (2013) CERKL Knockdown Causes Retinal Degeneration in Zebrafish. PLoS One. 8(5):e64048
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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