Gene
pfas
- ID
- ZDB-GENE-030131-4420
- Name
- phosphoribosylformylglycinamidine synthase
- Symbol
- pfas Nomenclature History
- Previous Names
-
- fd05a06
- si:dkey-183n20.16
- wu:fd05a06
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable phosphoribosylformylglycinamidine synthase activity. Predicted to be involved in purine nucleotide biosynthetic process. Predicted to be active in cytoplasm. Is expressed in brain; digestive system; eye; heart; and muscle. Orthologous to human PFAS (phosphoribosylformylglycinamidine synthase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Li et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR010918 | PurM-like, C-terminal domain |
Domain | IPR040707 | Phosphoribosylformylglycinamidine synthase, N-terminal |
Domain | IPR041609 | Phosphoribosylformylglycinamidine synthase, linker domain |
Domain | IPR055181 | FGAR-AT, PurM N-terminal-like domain |
Family | IPR010073 | Phosphoribosylformylglycinamidine synthase PurL |
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Domain Details Per Protein
Protein | Additional Resources | Length | Class I glutamine amidotransferase-like | FGAR-AT, PurM N-terminal-like domain | Phosphoribosylformylglycinamidine synthase, linker domain | Phosphoribosylformylglycinamidine synthase, N-terminal | Phosphoribosylformylglycinamidine synthase PurL | Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily | PurM-like, C-terminal domain | PurM-like, C-terminal domain superfamily | PurM-like, N-terminal domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q5TZ72 | InterPro | 1314 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-183N20 | ZFIN Curated Data | |
Encodes | EST | fd05a06 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001045202 (1) | 4602 nt | ||
Genomic | GenBank:BX322665 (1) | 192437 nt | ||
Polypeptide | UniProtKB:Q5TZ72 (1) | 1314 aa |
- Lewis, V.M., Saunders, L.M., Larson, T.A., Bain, E.J., Sturiale, S.L., Gur, D., Chowdhury, S., Flynn, J.D., Allen, M.C., Deheyn, D.D., Lee, J.C., Simon, J.A., Lippincott-Schwartz, J., Raible, D.W., Parichy, D.M. (2019) Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores. Proceedings of the National Academy of Sciences of the United States of America. 116(24):11806-11811
- Sanchez, N.E., Harty, B.L., O'Reilly-Pol, T., Ackerman, S.D., Herbert, A.L., Holmgren, M., Johnson, S.L., Gray, R.S., Monk, K.R. (2017) Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue. G3 (Bethesda). 7(10):3415-3425
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Li, Y., Li, G., Görling, B., Luy, B., Du, J., Yan, J. (2015) Integrative Analysis of Circadian Transcriptome and Metabolic Network Reveals the Role of De Novo Purine Synthesis in Circadian Control of Cell Cycle. PLoS Computational Biology. 11:e1004086
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