ZFIN is now using GRCz12tu for Genomic Data
Gene
guf1
- ID
- ZDB-GENE-030131-4289
- Name
- GTP binding elongation factor GUF1
- Symbol
- guf1 Nomenclature History
- Previous Names
-
- fc88c11
- im:6906935
- wu:fc88c11 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable mitochondrial ribosome binding activity. Predicted to be involved in positive regulation of translation. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 40. Orthologous to human GUF1 (GTP binding elongation factor GUF1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6906935 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 40 | Alliance | ?Developmental and epileptic encephalopathy 40 | 617065 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR031157 | Tr-type G domain, conserved site |
| Domain | IPR000640 | Elongation factor EFG, domain V-like |
| Domain | IPR000795 | Translational (tr)-type GTP-binding domain |
| Domain | IPR004161 | Translation elongation factor EFTu-like, domain 2 |
| Domain | IPR005225 | Small GTP-binding domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | EF-G domain III/V-like | Elongation factor 4 | Elongation factor 4, domain IV | Elongation factor EFG, domain V-like | GTP-binding protein LepA, C-terminal | LepA, C-terminal domain superfamily | P-loop containing nucleoside triphosphate hydrolase | Small GTP-binding domain | Translational (tr)-type GTP-binding domain | Translation elongation factor EFTu-like, domain 2 | Translation protein, beta-barrel domain superfamily | Tr-type G domain, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QKS4 | InterPro | 650 | ||||||||||||
| UniProtKB:E7FFK6 | InterPro | 672 | ||||||||||||
| UniProtKB:A0AB32T0L1 | InterPro | 658 | ||||||||||||
| UniProtKB:A0AB32T7J6 | InterPro | 680 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-185E18 | ZFIN Curated Data | |
| Encodes | EST | fc88c11 | ||
| Encodes | EST | IMAGE:6906935 | Thisse et al., 2004 |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068213292 (1) | GRCz12tu | 2727 nt | |
| Genomic | GenBank:BX088718 (2) | 172246 nt | ||
| Polypeptide | UniProtKB:A0AB32T7J6 (1) | 680 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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