Gene

tspearb

ID
ZDB-GENE-030131-4270
Name
thrombospondin-type laminin G domain and EAR repeats b
Symbol
tspearb Nomenclature History
Previous Names
  • tspear
  • fc86e12
  • si:ch211-244a17.4 (1)
  • wu:fc86e12
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Acts upstream of or within bone morphogenesis and regulation of odontogenesis. Predicted to be located in stereocilium. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 98; ectodermal dysplasia 14; and tooth agenesis. Orthologous to human TSPEAR (thrombospondin type laminin G domain and EAR repeats).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
omf107Allele with one deletionUnknownUnknownCRISPR
sa34570Allele with one point mutationUnknownPremature StopENU
sa41368Allele with one point mutationUnknownSplice SiteENU
1 - 3 of 3
Show
Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-tspearbJackson et al., 2023
1 - 1 of 1
Show
Human Disease
Associated With tspearb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 98 Alliance ?Deafness, autosomal recessive 98 614861
ectodermal dysplasia 14 Alliance Ectodermal dysplasia 14, hypohidrotic/hair/tooth/nail type 618180
Tooth agenesis, selective, 10 620173
1 - 3 of 3
Associated With tspearb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR048287 Thrombospondin-like, N-terminal domain
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Repeat IPR005492 Leucine-rich glioma-inactivated , EPTP repeat
Repeat IPR009039 EAR
1 - 4 of 4
Domain Details Per Protein
Protein Additional Resources Length Concanavalin A-like lectin/glucanase domain superfamily EAR Leucine-rich glioma-inactivated , EPTP repeat Thrombospondin-like, N-terminal domain
UniProtKB:E7F9F5 InterPro 666
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 9
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA tspearb-201 (1) Ensembl 5,043 nt
mRNA tspearb-202 (1) Ensembl 2,234 nt
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-244A17ZFIN Curated Data
EncodesESTfc86e12
1 - 2 of 2
Show
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanTSPEAR21
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseTspear10
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
1 - 2 of 2
Show