Gene

pars2

ID

ZDB-GENE-030131-4219

Name

prolyl-tRNA synthetase 2, mitochondrial

Symbol

pars2 Nomenclature History

Previous Names

fc83e06
wu:fc83e06
zgc:77163 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to enable proline-tRNA ligase activity. Predicted to be involved in prolyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 75. Orthologous to human PARS2 (prolyl-tRNA synthetase 2, mitochondrial).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:77163 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

No data available

Sequence Targeting Reagents

No data available

Human Disease

Associated With pars2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental and epileptic encephalopathy 75	Alliance	Developmental and epileptic encephalopathy 75	618437

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Associated With pars2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002314	Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
Domain	IPR004154	Anticodon-binding
Domain	IPR006195	Aminoacyl-tRNA synthetase, class II
Domain	IPR033730	Prokaryote proline-tRNA ligase core domain
Family	IPR002316	Proline-tRNA ligase, class IIa

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Domain Details Per Protein

Protein	Additional Resources	Length	Aminoacyl-tRNA synthetase, class II	Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)	Anticodon-binding	Anticodon-binding domain superfamily	Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)	Prokaryote proline-tRNA ligase core domain	Proline-tRNA ligase, class IIa	Proline-tRNA synthetase
UniProtKB:Q6P0C4	InterPro	477
UniProtKB:A0AB32TSA4	InterPro	403

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 6

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	pars2-201 (1) Ensembl	Ensembl		1,711 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-218B7	BX088595	ZFIN Curated Data
Encodes	EST	fc83e06	AI943042
Encodes	cDNA	MGC:77163	BC065673	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_205555 (1)	1719 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX088595 (1)	143341 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q6P0C4 (1)	477 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	PARS2	1	Ensembl:ENSG00000162396 Gene:25973 HGNC:30563 OMIM:612036	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)
Mouse	Pars2	4	Ensembl:ENSMUSG00000043572 Gene:230577 MGI:2386296	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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