Gene
fstl1a
- ID
- ZDB-GENE-030131-4148
- Name
- follistatin-like 1a
- Symbol
- fstl1a Nomenclature History
- Previous Names
-
- fstl1 (1)
- wu:fc75h02
- zgc:110703
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable heparin binding activity. Acts upstream of or within notochord cell differentiation; positive regulation of adipose tissue development; and regulation of BMP signaling pathway. Located in extracellular region. Is expressed in several structures, including central nervous system; cranium; fin fold pectoral fin bud; mesenchyme; and mesoderm. Orthologous to human FSTL1 (follistatin like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Guggeri et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002048 | EF-hand domain |
| Domain | IPR002350 | Kazal domain |
| Domain | IPR003645 | Follistatin-like, N-terminal |
| Domain | IPR015369 | Follistatin/Osteonectin EGF domain |
| Family | IPR050653 | Protease Inhibitors and Growth Factor Antagonists |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR036058 | Kazal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | EF-hand domain | EF-hand domain pair | Follistatin-like, N-terminal | Follistatin/Osteonectin EGF domain | Kazal domain | Kazal domain superfamily | Protease Inhibitors and Growth Factor Antagonists |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q567W5 | InterPro | 314 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fstl1a-201
(1)
|
Ensembl | 1,511 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Woods, et al. (2005. Genome Res. 15:1307-1314.) report this gene to be fst based on amino acid similarity to human FST. Subsequent analysis suggests it is the ortholog of human FSTL1 and mouse Fstl1 based on amino acid similarity and conserved synteny.