Gene
fstl1a
- ID
- ZDB-GENE-030131-4148
- Name
- follistatin-like 1a
- Symbol
- fstl1a Nomenclature History
- Previous Names
-
- fstl1 (1)
- wu:fc75h02
- zgc:110703
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable heparin binding activity. Acts upstream of or within notochord cell differentiation; positive regulation of adipose tissue development; and regulation of BMP signaling pathway. Located in extracellular region. Is expressed in several structures, including central nervous system; cranium; fin fold pectoral fin bud; mesenchyme; and mesoderm. Orthologous to human FSTL1 (follistatin like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Guggeri et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la013698Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la013699Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021250Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa12164 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32756 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zf4105 | Allele with one insertion | Exon 3 | Premature Stop | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EF-hand domain | EF-hand domain pair | Follistatin-like, N-terminal | Follistatin/Osteonectin EGF domain | Kazal domain | Kazal domain superfamily | Protease Inhibitors and Growth Factor Antagonists |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q567W5 | InterPro | 314 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fstl1a-201
(1)
|
Ensembl | 1,511 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-191D11 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-100G3 | ZFIN Curated Data | |
| Encodes | EST | fb71d01 | Rauch et al., 2003 | |
| Encodes | EST | fc75h02 | ||
| Encodes | cDNA | MGC:110703 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001017860 (1) | 1497 nt | ||
| Genomic | GenBank:CT737229 | 90775 nt | ||
| Polypeptide | UniProtKB:Q567W5 (1) | 314 aa |
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Woods, et al. (2005. Genome Res. 15:1307-1314.) report this gene to be fst based on amino acid similarity to human FST. Subsequent analysis suggests it is the ortholog of human FSTL1 and mouse Fstl1 based on amino acid similarity and conserved synteny.
- Bao, J., Su, B., Chen, Z., Sun, Z., Peng, J., Zhao, S. (2024) A UTP3-dependent nucleolar translocation pathway facilitates pre-rRNA 5'ETS processing. Nucleic acids research. 52(16):9671-9694
- Guggeri, L., Sosa-Redaelli, I., Cárdenas-Rodríguez, M., Alonso, M., González, G., Naya, H., Prieto-Echagüe, V., Lepanto, P., Badano, J.L. (2024) Follistatin like-1 (Fstl1) regulates adipose tissue development in zebrafish. Adipocyte. 13:24358622435862
- Cao, Y., Xia, Y., Balowski, J.J., Ou, J., Song, L., Safi, A., Curtis, T., Crawford, G.E., Poss, K.D., Cao, J. (2022) Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration. Development (Cambridge, England). 149(4)
- Carril Pardo, C.A., Massoz, L., Dupont, M.A., Bergemann, D., Bourdouxhe, J., Lavergne, A., Tarifeño-Saldivia, E., Helker, C.S., Stainier, D.Y., Peers, B., Voz, M.M., Manfroid, I. (2022) A δ-cell subpopulation with pro-β cell identity contributes to efficient age-independent recovery in a zebrafish diabetes model. eLIFE. 11:
- Hou, J., Liu, H., Zhang, S., Liu, X., Hayat, T., Alsaedi, A., Wang, X. (2019) Mechanism of toxic effects of Nano-ZnO on cell cycle of zebrafish (Danio rerio). Chemosphere. 229:206-213
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Ernens, I., Lumley, A.I., Devaux, Y. (2018) Restoration of cardiac function after anaemia-induced heart failure in zebrafish. Journal of Molecular and Cellular Cardiology. 121:223-232
- Wagner, D.E., Weinreb, C., Collins, Z.M., Briggs, J.A., Megason, S.G., Klein, A.M. (2018) Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo. Science (New York, N.Y.). 360(6392):981-987
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Black, J.C., Atabakhsh, E., Kim, J., Biette, K.M., Van Rechem, C., Ladd, B., Burrowes, P.D., Donado, C., Mattoo, H., Kleinstiver, B.P., Song, B., Andriani, G., Joung, J.K., Iliopoulos, O., Montagna, C., Pillai, S., Getz, G., Whetstine, J.R. (2015) Hypoxia drives transient site-specific copy gain and drug-resistant gene expression. Genes & Development. 29:1018-31
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