Gene
dhx57
- ID
- ZDB-GENE-030131-4078
- Name
- DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
- Symbol
- dhx57 Nomenclature History
- Previous Names
-
- fc68d07
- si:ch211-250c4.7
- wu:fc68d07 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity and helicase activity. Orthologous to human DHX57 (DExH-box helicase 57).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la018753Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa9815 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16244 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17834 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17853 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22221 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30968 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35420 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | DEAD-box helicase, OB fold | DEAD/DEAH box helicase domain | E3 ligase, CCCH-type zinc finger | Helicase-associated domain | Helicase associated domain (HA2), winged-helix domain | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | RWD domain | Ubiquitin-associated domain | Ubiquitin-conjugating enzyme/RWD-like | Zinc finger, CCCH-type | Zinc finger, CCCH-type superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q4U2 | InterPro | 891 | |||||||||||||
| UniProtKB:A0A8M9Q4T8 | InterPro | 515 | |||||||||||||
| UniProtKB:A0A2R8Q3V8 | InterPro | 1431 | |||||||||||||
| UniProtKB:F1QCB1 | InterPro | 1430 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-243F3 | ZFIN Curated Data | |
| Contained in | BAC | CH211-250C4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-72O5 | ZFIN Curated Data | |
| Encodes | EST | fc68d07 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021480720 (1) | 4889 nt | ||
| Genomic | GenBank:AL935288 (2) | 181644 nt | ||
| Polypeptide | UniProtKB:A0A2R8Q3V8 (1) | 1431 aa |
- Sánchez, E., Azcona, L.J., Paisán-Ruiz, C. (2018) Pla2g6 Deficiency in Zebrafish Leads to Dopaminergic Cell Death, Axonal Degeneration, Increased β-Synuclein Expression, and Defects in Brain Functions and Pathways. Molecular neurobiology. 55(8):6734-6754
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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