ZFIN is now using GRCz12tu for Genomic Data
Gene
calr
- ID
- ZDB-GENE-030131-4042
- Name
- calreticulin
- Symbol
- calr Nomenclature History
- Previous Names
-
- calrl2
- fc66d10
- wu:fc66d10
- wu:fj50c03
- zgc:66153
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable calcium ion binding activity. Predicted to be involved in ERAD pathway and protein folding. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including hatching gland; nervous system; notochord; polster; and trigeminal placode. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung cancer (multiple); and thrombocytosis. Orthologous to human CALR (calreticulin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66153 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| essential thrombocythemia | Alliance | Thrombocythemia, somatic | 187950 |
| myelofibrosis | Alliance | Myelofibrosis, somatic | 254450 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018124 | Calreticulin/calnexin, conserved site |
| Family | IPR001580 | Calreticulin/calnexin |
| Family | IPR009169 | Calreticulin |
| Homologous_superfamily | IPR009033 | Calreticulin/calnexin, P domain superfamily |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Calreticulin | Calreticulin/calnexin | Calreticulin/calnexin, conserved site | Calreticulin/calnexin, P domain superfamily | Concanavalin A-like lectin/glucanase domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:F1Q8W8 | InterPro | 417 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers