Gene
nsun2
- ID
- ZDB-GENE-030131-4017
- Name
- NOP2/Sun RNA methyltransferase 2
- Symbol
- nsun2 Nomenclature History
- Previous Names
-
- wu:fc65a08
- zgc:55517
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable tRNA (cytidine-5-)-methyltransferase activity and tRNA binding activity. Predicted to be involved in tRNA methylation. Predicted to act upstream of or within RNA methylation and tRNA processing. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 5. Orthologous to human NSUN2 (NOP2/Sun RNA methyltransferase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55517 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb340 | Allele with one delins | Exon 3 | Unknown | CRISPR | |
| ihb341 | Allele with one delins | Exon 3 | Unknown | CRISPR | |
| mn1104Gt | Transgenic insertion | Unknown | Unknown | DNA | |
| sa3016 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14653 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15958 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa36858 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa43300 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nsun2 | Zebrafish Nomenclature Committee | |
| CRISPR2-nsun2 | Zebrafish Nomenclature Committee |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive intellectual developmental disorder 5 | Alliance | Intellectual developmental disorder, autosomal recessive 5 | 611091 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001678 | SAM-dependent methyltransferase RsmB-F/NOP2-type domain |
| Domain | IPR049560 | SAM-dependent methyltransferase RsmB-F/NOP2-type, catalytic core |
| Family | IPR023267 | RNA (C5-cytosine) methyltransferase |
| Family | IPR023270 | tRNA (C5-cytosine) methyltransferase, NCL1 |
| Homologous_superfamily | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | RNA (C5-cytosine) methyltransferase | S-adenosyl-L-methionine-dependent methyltransferase superfamily | SAM-dependent methyltransferase RsmB-F/NOP2-type, catalytic core | SAM-dependent methyltransferase RsmB-F/NOP2-type domain | tRNA (C5-cytosine) methyltransferase, NCL1 |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZTI1 | InterPro | 706 | |||||
| UniProtKB:A5PMI3 | InterPro | 766 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-56D18 | ZFIN Curated Data | |
| Encodes | EST | fc65a08 | ||
| Encodes | cDNA | MGC:55517 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191743 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199711 (1) | 2905 nt | ||
| Genomic | GenBank:BX511155 (1) | 205235 nt | ||
| Polypeptide | UniProtKB:A5PMI3 (1) | 766 aa |
- Sabharwal, A., Campbell, J.M., Schwab, T.L., WareJoncas, Z., Wishman, M.D., Ata, H., Liu, W., Ichino, N., Hunter, D.E., Bergren, J.D., Urban, M.D., Urban, R.M., Holmberg, S.R., Kar, B., Cook, A., Ding, Y., Xu, X., Clark, K.J., Ekker, S.C. (2022) A Primer Genetic Toolkit for Exploring Mitochondrial Biology and Disease Using Zebrafish. Genes. 13(8):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Dildrop, R., and Ruther, U. (2004) Organization of Iroquois genes in fish. Development genes and evolution. 214(6):267-276
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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