Gene

ptprn2

ID
ZDB-GENE-030131-3758
Name
protein tyrosine phosphatase receptor type N2
Symbol
ptprn2 Nomenclature History
Previous Names
  • fc52a08
  • IA-2[b] (1)
  • im:7153814
  • wu:fc52a08 (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have protein tyrosine phosphatase activity. Predicted to be involved in insulin secretion involved in cellular response to glucose stimulus and protein dephosphorylation. Predicted to localize to integral component of membrane and secretory granule. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Is expressed in brain. Orthologous to human PTPRN2 (protein tyrosine phosphatase receptor type N2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ptprn2 Human Ortholog
No data available
Associated With ptprn2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR016130 Protein-tyrosine phosphatase, active site
Domain IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
Domain IPR000387 Tyrosine-specific protein phosphatases domain
Domain IPR003595 Protein-tyrosine phosphatase, catalytic
Domain IPR021613 Protein-tyrosine phosphatase receptor IA-2 ectodomain
Domain IPR029403 RESP18 domain
Family IPR033522 Receptor-type tyrosine-protein phosphatase-like N/N2
Homologous_superfamily IPR029021 Protein-tyrosine phosphatase-like
Homologous_superfamily IPR038112 Protein-tyrosine phosphatase receptor IA-2, ectodomain superfamily
Domain Details Per Protein
Protein Length Protein-tyrosine phosphatase, active site Protein-tyrosine phosphatase, catalytic Protein-tyrosine phosphatase-like Protein-tyrosine phosphatase receptor IA-2 ectodomain Protein-tyrosine phosphatase receptor IA-2, ectodomain superfamily Receptor-type tyrosine-protein phosphatase-like N/N2 RESP18 domain Tyrosine-specific protein phosphatase, PTPase domain Tyrosine-specific protein phosphatases domain
UniProtKB:F1QIB8
UniProtKB:A3KPJ4 1027
UniProtKB:A0A8M9QGN0 989
UniProtKB:A0A8M9Q7I8 1011
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations