ZFIN is now using GRCz12tu for Genomic Data
Gene
adgrg1
- ID
- ZDB-GENE-030131-3671
- Name
- adhesion G protein-coupled receptor G1
- Symbol
- adgrg1 Nomenclature History
- Previous Names
-
- fc49b10
- gpr56
- wu:fc49b10
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable G protein-coupled receptor activity. Acts upstream of or within glial cell development; regulation of oligodendrocyte progenitor proliferation; and swimming behavior. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including heart; liver; nervous system; pleuroperitoneal region; and trigeminal placode. Human ortholog(s) of this gene implicated in bilateral frontoparietal polymicrogyria and bilateral perisylvian polymicrogyria. Orthologous to human ADGRG1 (adhesion G protein-coupled receptor G1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7159602 (16 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| bilateral frontoparietal polymicrogyria | Alliance | Cortical dysplasia, complex, with other brain malformations 14A, (bilateral frontoparietal) | 606854 |
| bilateral perisylvian polymicrogyria | Alliance | Cortical dysplasia, complex, with other brain malformations 14B, (bilateral perisylvian) | 615752 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000203 | GPS motif |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001315 | CARD domain |
| Domain | IPR017981 | GPCR, family 2-like, 7TM |
| Family | IPR000832 | GPCR, family 2, secretin-like |
| Family | IPR051681 | Serine/Threonine Kinases and Pseudokinases |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
| Homologous_superfamily | IPR046338 | GAIN domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | CARD domain | Death-like domain superfamily | GAIN domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPS motif | Protein kinase domain | Protein kinase-like domain superfamily | Serine/Threonine Kinases and Pseudokinases | Serine-threonine/tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q59I63 | InterPro | 648 | ||||||||||
| UniProtKB:F1QZM9 | InterPro | 648 | ||||||||||
| UniProtKB:A0A1D5NSB4 | InterPro | 513 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adgrg1-201
(1)
|
Ensembl | 2,823 nt | ||
| mRNA |
adgrg1-202
(1)
|
Ensembl | 4,138 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers