ZFIN is now using GRCz12tu for Genomic Data
Gene
gldc
- ID
- ZDB-GENE-030131-340
- Name
- glycine dehydrogenase (decarboxylating)
- Symbol
- gldc Nomenclature History
- Previous Names
-
- fb23b05
- wu:fb23b05
- zgc:66198
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable glycine binding activity; glycine dehydrogenase (decarboxylating) activity; and pyridoxal phosphate binding activity. Acts upstream of or within cartilage development; cloaca development; and pronephric nephron tubule development. Predicted to be part of glycine cleavage complex. Predicted to be active in mitochondrion. Is expressed in central nervous system; digestive system; and pronephros. Used to study glycine encephalopathy. Human ortholog(s) of this gene implicated in glycine encephalopathy and glycine encephalopathy 1. Orthologous to human GLDC (glycine decarboxylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66198 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| glycine encephalopathy 1 | Alliance | Glycine encephalopathy1 | 605899 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| glycine encephalopathy | gldcudm301/udm301 | standard conditions | Riché et al., 2018 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR049315 | Glycine cleavage system P-protein, N-terminal domain |
| Domain | IPR049316 | Glycine dehydrogenase, C-terminal domain |
| Family | IPR020581 | Glycine cleavage system P protein |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
Domain Details Per Protein
| Protein | Additional Resources | Length | Glycine cleavage system P protein | Glycine cleavage system P-protein, N-terminal domain | Glycine dehydrogenase, C-terminal domain | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0G2KSN1 | InterPro | 981 | ||||||
| UniProtKB:E7FAR0 | InterPro | 986 | ||||||
| UniProtKB:Q6PFN9 | InterPro | 983 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers