Gene
cpsf3
- ID
- ZDB-GENE-030131-3275
- Name
- cleavage and polyadenylation specific factor 3
- Symbol
- cpsf3 Nomenclature History
- Previous Names
-
- si:dkey-81b15.1
- wu:fc32f10
- zgc:101655
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have 5'-3' exonuclease activity; RNA binding activity; and endoribonuclease activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage and mRNA polyadenylation. Predicted to localize to mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human CPSF3 (cleavage and polyadenylation specific factor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with microcephaly, hypotonia, nystagmus, and seizures | 619876 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001279 | Metallo-beta-lactamase |
| Domain | IPR011108 | Zn-dependent metallo-hydrolase, RNA specificity domain |
| Domain | IPR021718 | Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term |
| Domain | IPR022712 | Beta-Casp domain |
| Homologous_superfamily | IPR036866 | Ribonuclease Z/Hydroxyacylglutathione hydrolase-like |
Domain Details Per Protein
| Protein | Length | Beta-Casp domain | Metallo-beta-lactamase | Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term | Ribonuclease Z/Hydroxyacylglutathione hydrolase-like | Zn-dependent metallo-hydrolase, RNA specificity domain |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6DRG6
|
690 |
Interactions and Pathways
No data available
Plasmids
No data available