Gene

cpsf3

ID
ZDB-GENE-030131-3275
Name
cleavage and polyadenylation specific factor 3
Symbol
cpsf3 Nomenclature History
Previous Names
  • si:dkey-81b15.1
  • wu:fc32f10
  • zgc:101655
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have 5'-3' exonuclease activity; RNA binding activity; and endoribonuclease activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage and mRNA polyadenylation. Predicted to localize to mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human CPSF3 (cleavage and polyadenylation specific factor 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cpsf3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neurodevelopmental disorder with microcephaly, hypotonia, nystagmus, and seizures 619876
Associated With cpsf3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001279 Metallo-beta-lactamase
Domain IPR011108 Zn-dependent metallo-hydrolase, RNA specificity domain
Domain IPR021718 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
Domain IPR022712 Beta-Casp domain
Homologous_superfamily IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Domain Details Per Protein
Protein Length Beta-Casp domain Metallo-beta-lactamase Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Ribonuclease Z/Hydroxyacylglutathione hydrolase-like Zn-dependent metallo-hydrolase, RNA specificity domain
UniProtKB:Q5U3T4 690
UniProtKB:Q6DRG6 690
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations