Gene
hnf1bb
- ID
- ZDB-GENE-030131-3003
- Name
- HNF1 homeobox Bb
- Symbol
- hnf1bb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior pattern specification involved in pronephros development. Predicted to be active in nucleus. Is expressed in intermediate mesoderm; pronephros; and rhombomere 5. Human ortholog(s) of this gene implicated in kidney disease; pancreas disease; renal cell carcinoma; renal cysts and diabetes syndrome; and type 2 diabetes mellitus. Orthologous to human HNF1B (HNF1 homeobox B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-hnf1ba,hnf1bb | N/A | Sander et al., 2019 |
| MO1-hnf1bb | N/A | (4) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nonpapillary renal cell carcinoma | Alliance | {Renal cell carcinoma} | 144700 |
| renal cysts and diabetes syndrome | Alliance | Renal cysts and diabetes syndrome | 137920 |
| type 2 diabetes mellitus | Alliance | Type 2 diabetes mellitus | 125853 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001356 | Homeodomain |
| Domain | IPR006897 | Hepatocyte nuclear factor 1, beta isoform, C-terminal |
| Domain | IPR006899 | Hepatocyte nuclear factor 1, N-terminal |
| Domain | IPR044866 | HNF-1, dimerization domain |
| Domain | IPR044869 | HNF-1, POU-specific (POUs) atypical domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Hepatocyte nuclear factor 1 | Hepatocyte nuclear factor 1, beta isoform, C-terminal | Hepatocyte nuclear factor 1, N-terminal | Hepatocyte nuclear factor 1, N-terminal domain superfamily | HNF-1, dimerization domain | HNF-1, POU-specific (POUs) atypical domain | Homedomain-like superfamily | Homeodomain | Lambda repressor-like, DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q8UW00 | InterPro | 532 | |||||||||
| UniProtKB:A0AB32TEZ6 | InterPro | 508 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hnf1bb-201
(1)
|
Ensembl | 1,439 nt | ||
| mRNA |
hnf1bb-202
(1)
|
Ensembl | 4,162 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_194372 (1) | 3628 nt | ||
| Genomic | GenBank:CU694492 (1) | 96581 nt | ||
| Polypeptide | UniProtKB:Q8UW00 (1) | 532 aa |
- Sander, V., Salleh, L., Naylor, R.W., Schierding, W., Sontam, D.M., O'Sullivan, J.M., Davidson, A.J. (2019) Transcriptional profiling of the zebrafish proximal tubule. American journal of physiology. Renal physiology. 317(2):F478-F488
- Naylor, R.W., Chang, H.G., Qubisi, S., Davidson, A.J. (2018) A novel mechanism of gland formation in zebrafish involving transdifferentiation of renal epithelial cells and live cell extrusion. eLIFE. 7:
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Sander, V., Patke, S., Sahu, S., Teoh, C.L., Peng, Z., Chang, Y.T., Davidson, A.J. (2015) The small molecule probe PT-Yellow labels the renal proximal tubules in zebrafish. Chemical communications (Cambridge, England). 51(2):395-8
- Samarut, E., Gaudin, C., Hughes, S., Gillet, B., de Bernard, S., Jouve, P.E., Buffat, L., Allot, A., Lecompte, O., Berekelya, L., Rochette-Egly, C., and Laudet, V. (2014) Retinoic acid receptor subtype-specific transcriptotypes in the early zebrafish embryo. Molecular endocrinology (Baltimore, Md.). 28(2):260-272
- Wang, Y., Sun, Z.H., Zhou, L., Li, Z., Gui, J.F. (2014) Grouper tshbeta Promoter-Driven Transgenic Zebrafish Marks Proximal Kidney Tubule Development. PLoS One. 9:e97806
- Naylor, R.W., Przepiorski, A., Ren, Q., Yu, J., and Davidson, A.J. (2013) HNF1beta Is Essential for Nephron Segmentation during Nephrogenesis. Journal of the American Society of Nephrology : JASN. 24(1):77-87
- Choe, S.K., Zhang, X., Hirsch, N., Straubhaar, J., and Sagerström, C.G. (2011) A screen for hoxb1-regulated genes identifies ppp1r14al as a regulator of the rhombomere 4 Fgf-signaling center. Developmental Biology. 358(2):356-67
- Wingert, R.A., and Davidson, A.J. (2011) Zebrafish nephrogenesis involves dynamic spatiotemporal expression changes in renal progenitors and essential signals from retinoic acid and irx3b. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(8):2011-2027
- Feng, L., Hernandez, R.E., Waxman, J.S., Yelon, D., and Moens, C.B. (2010) Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism. Developmental Biology. 338(1):1-14
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