Gene

bcar1

ID

ZDB-GENE-030131-2774

Name

BCAR1 scaffold protein, Cas family member

Symbol

bcar1 Nomenclature History

Previous Names

fc17f11
wu:fc17f11 (1)
zgc:175192

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to be involved in actin filament reorganization; cell migration; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to colocalize with plasma membrane. Human ortholog(s) of this gene implicated in breast ductal carcinoma. Orthologous to human BCAR1 (BCAR1 scaffold protein, Cas family member).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from O'Hare et al., 2016

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from Wisniewski et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bcar1 Human Ortholog

No data available

Associated With bcar1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001452	SH3 domain
Domain	IPR014928	Serine rich protein interaction domain
Domain	IPR021901	CAS family, C-terminal
Domain	IPR035745	BCAR1, SH3 domain
Family	IPR037362	CAS family
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR038319	CAS, serine rich four helix bundle domain superfamily