Gene
prpf40a
- ID
- ZDB-GENE-030131-274
- Name
- PRP40 pre-mRNA processing factor 40 homolog A
- Symbol
- prpf40a Nomenclature History
- Previous Names
-
- fb18h07
- fe47a12
- fnbp3 (1)
- wu:fb18h07
- wu:fe47a12
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within mRNA cis splicing, via spliceosome. Predicted to be located in nuclear matrix and nuclear speck. Predicted to be part of U1 snRNP and U2-type prespliceosome. Orthologous to human PRPF40A (pre-mRNA processing factor 40 homolog A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56384 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1197 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13254 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31699 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41344 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | FF domain | FF domain superfamily | Pre-mRNA-processing factor Prp40 | WW domain | WW domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z7Z9 | InterPro | 749 | |||||
| UniProtKB:Q7ZUE4 | InterPro | 851 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prpf40a-201
(1)
|
Ensembl | 3,285 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-279A7 | ZFIN Curated Data | |
| Encodes | EST | fb18h07 | ||
| Encodes | cDNA | MGC:56384 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_198356 (1) | 3281 nt | ||
| Genomic | GenBank:CR925815 (2) | 178160 nt | ||
| Polypeptide | UniProtKB:Q7ZUE4 (1) | 851 aa |
- Figueroa, R.J., Carrasco-Avino, G., Wichmann, I.A., Lange, M., Owen, G.I., Siekmann, A.F., Corvalán, A.H., Opazo, J.C., Amigo, J.D. (2017) Reprimo tissue-specific expression pattern is conserved between zebrafish and human. PLoS One. 12:e0178274
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Yeo, G.H., Cheah, F.S., Winkler, C., Jabs, E.W., Venkatesh, B., and Chong, S.S. (2009) Phylogenetic and evolutionary relationships and developmental expression patterns of the zebrafish twist gene family. Development genes and evolution. 219(6):289-300
- Katoh, M. and Katoh M. (2003) Identification and characterization of human FNBP3 gene in silico. International journal of molecular medicine. 12(4):651-656
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
- Tallafuss, A., Wilm, T.P., Crozatier, M., Pfeffer, P., Wassef, M., and Bally-Cuif, L. (2001) The zebrafish buttonhead-like factor Bts1 is an early regulator of pax2.1 expression during mid-hindbrain development. Development (Cambridge, England). 128(20):4021-4034
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