Gene
slc20a1b
- ID
- ZDB-GENE-030131-260
- Name
- solute carrier family 20 member 1b
- Symbol
- slc20a1b Nomenclature History
- Previous Names
-
- cb104 (1)
- slc20a1
- fa05g12
- sb:cb104
- wu:fa05g12
- wu:fb18f05
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable phosphate transmembrane transporter activity. Predicted to be involved in phosphate ion transmembrane transport. Predicted to act upstream of or within phosphate ion transport. Predicted to be located in membrane. Is expressed in central nervous system; post-vent region; and somite. Orthologous to human SLC20A1 (solute carrier family 20 member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Rieke et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa11277 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17030 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31775 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| smu07 | Allele with one point mutation | Exon 2 | Unknown | not specified | |
| smu08 | Allele with one delins | Exon 2 | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001204 | Phosphate transporter |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Phosphate transporter |
|---|---|---|---|
| UniProtKB:F1QI67 | InterPro | 665 | |
| UniProtKB:Q6PFM1 | InterPro | 665 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc20a1b-201
(1)
|
Ensembl | 3,782 nt | ||
| mRNA |
slc20a1b-204
(1)
|
Ensembl | 2,815 nt | ||
| ncRNA |
slc20a1b-002
(1)
|
Ensembl | 501 nt | ||
| ncRNA |
slc20a1b-003
(1)
|
Ensembl | 516 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-200L5 | ZFIN Curated Data | |
| Encodes | EST | cb104 | Thisse et al., 2001 | |
| Encodes | EST | fa05g12 | ZFIN Curated Data | |
| Encodes | EST | fb18f05 | ||
| Encodes | EST | fi25e09 | ||
| Encodes | cDNA | MGC:66257 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212588 (1) | 3801 nt | ||
| Genomic | GenBank:CR925808 (1) | 170902 nt | ||
| Polypeptide | UniProtKB:F1QI67 (1) | 665 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | SLC20A1 | 2 | Amino acid sequence comparison (2) |
- Chen, J., Li, G., Lian, J., Ma, N., Huang, Z., Li, J., Wen, Z., Zhang, W., Zhang, Y. (2021) Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish. Science China. Life sciences. 64(12):2186-2201
- Rieke, J.M., Zhang, R., Braun, D., Yilmaz, Ö., Japp, A.S., Lopes, F.M., Pleschka, M., Hilger, A.C., Schneider, S., Newman, W.G., Beaman, G.M., Nordenskjöld, A., Ebert, A.K., Promm, M., Rösch, W.H., Stein, R., Hirsch, K., Schäfer, F.M., Schmiedeke, E., Boemers, T.M., Lacher, M., Kluth, D., Gosemann, J.H., Anderberg, M., Barker, G., Holmdahl, G., Läckgren, G., Keene, D., Cervellione, R.M., Giorgio, E., Di Grazia, M., Feitz, W.F.J., Marcelis, C.L.M., Van Rooij, I.A.L.M., Bökenkamp, A., Beckers, G.M.A., Keegan, C.E., Sharma, A., Dakal, T.C., Wittler, L., Grote, P., Zwink, N., Jenetzky, E., Brusco, A., Thiele, H., Ludwig, M., Schweizer, U., Woolf, A.S., Odermatt, B., Reutter, H. (2020) SLC20A1 Is Involved in Urinary Tract and Urorectal Development. Frontiers in cell and developmental biology. 8:567
- Xu, H., Liu, X., Jia, Y., Dong, F., Xu, J., Wu, X., Yang, Y., Zheng, Y. (2018) Fipronil-induced toxic effects in zebrafish (Danio rerio) larvae by using digital gene expression profiling. The Science of the total environment. 639:550-559
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports. 7:4967
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Yang, L., Kemadjou, J.R., Zinsmeister, C., Legradi, J., Bauer, M., Muller, F., Pankratz, M., Jakel, J., and Straehle, U. (2007) Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo. Genome biology. 8(10):R227
- Nichane, M., Van Campenhout, C., Pendeville, H., Voz, M.L., and Bellefroid, E.J. (2006) The Na(+)/PO(4) cotransporter SLC20A1 gene labels distinct restricted subdomains of the developing pronephros in Xenopus and zebrafish embryos. Gene expression patterns : GEP. 6(7):667-672
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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