ZFIN is now using GRCz12tu for Genomic Data
Gene
sult1st1
- ID
- ZDB-GENE-030131-2144
- Name
- sulfotransferase family 1, cytosolic sulfotransferase 1
- Symbol
- sult1st1 Nomenclature History
- Previous Names
-
- fb98b02
- fk46b09
- wu:fb98b02
- wu:fk46b09
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables sulfotransferase activity. Involved in xenobiotic metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; gastrointestinal system cancer (multiple); lung cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including SULT1A1 (sulfotransferase family 1A member 1); SULT1A2 (sulfotransferase family 1A member 2); and SULT1A3 (sulfotransferase family 1A member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7137263 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa38711 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | P-loop containing nucleoside triphosphate hydrolase | Sulfotransferase domain |
|---|---|---|---|---|
| UniProtKB:Q6PH37 | InterPro | 299 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sult1st1-201
(1)
|
Ensembl | 1,614 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-196G2 | ZFIN Curated Data | |
| Encodes | EST | fb98b02 | ||
| Encodes | EST | fk46b09 | ||
| Encodes | EST | IMAGE:7137263 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:66017 | ZFIN Curated Data |
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- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_182941 (1) | 1290 nt | ||
| Genomic | GenBank:AL935148 (1) | 195396 nt | ||
| Polypeptide | UniProtKB:Q6PH37 (1) | 299 aa |
No data available
- Bereketoglu, C., Pradhan, A., Olsson, P.E. (2020) Nonsteroidal anti-inflammatory drugs (NSAIDs) cause male-biased sex differentiation in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 223:105476
- Kim, C., Choe, H., Park, J., Kim, G., Kim, K., Jeon, H.J., Moon, J.K., Kim, M.J., Lee, S.E. (2020) Molecular mechanisms of developmental toxicities of azoxystrobin and pyraclostrobin toward zebrafish (Danio rerio) embryos: Visualization of abnormal development using two transgenic lines. Environmental pollution (Barking, Essex : 1987). 270:116087
- Kim, Y.C., Lee, S.R., Jeon, H.J., Kim, K., Kim, M.J., Choi, S.D., Lee, S.E. (2020) Acute toxicities of fluorene, fluorene-1-carboxylic acid, and fluorene-9-carboxylic acid on zebrafish embryos (Danio rerio): Molecular mechanisms of developmental toxicities of fluorene-1-carboxylic acid. Chemosphere. 260:127622
- Wu, L., Chen, H., Ru, H., Li, Y., Yao, F., Ni, Z., Zhong, L. (2020) Sex-specific effects of triphenyltin chloride (TPT) on thyroid disruption and metabolizing enzymes in adult zebrafish (Danio rerio). Toxicology letters. 331:143-151
- Hamid, N., Junaid, M., Pei, D.S. (2019) Individual and combined mechanistic toxicity of sulfonamides and their implications for ecological risk assessment in the Three Gorges Reservoir Area (TGRA), China. Journal of hazardous materials. 382:121106
- Junaid, M., Wang, Y., Hamid, N., Deng, S., Li, W.G., Pei, D.S. (2019) Prioritizing selected PPCPs on the basis of environmental and toxicogenetic concerns: A toxicity estimation to confirmation approach. Journal of hazardous materials. 380:120828
- Wang, J., Shi, G., Yao, J., Sheng, N., Cui, R., Su, Z., Guo, Y., Dai, J. (2019) Perfluoropolyether carboxylic acids (novel alternatives to PFOA) impair zebrafish posterior swim bladder development via thyroid hormone disruption. Environment International. 134:105317
- Yamauchi, K., Katsumata, S., Ozaki, M. (2019) A prototype of the mammalian sulfotransferase 1 (SULT1) family in Xenopus laevis: molecular and enzymatic properties of XlSULT1B.S. Genes & genetic systems. 94(5):207-217
- Liu, Y., Junaid, M., Wang, Y., Tang, Y.M., Bian, W.P., Xiong, W.X., Huang, H.Y., Chen, C.D., Pei, D.S. (2018) New toxicogenetic insights and ranking of the selected pharmaceuticals belong to the three different classes: A toxicity estimation to confirmation approach. Aquatic toxicology (Amsterdam, Netherlands). 201:151-161
- Verbueken, E., Bars, C., Ball, J.S., Periz-Stanacev, J., Marei, W.F.A., Tochwin, A., Gabriëls, I.J., Michiels, E.D.G., Stinckens, E., Vergauwen, L., Knapen, D., Van Ginneken, C.J., Van Cruchten, S.J. (2018) From mRNA Expression of Drug Disposition Genes to In Vivo Assessment of CYP-Mediated Biotransformation during Zebrafish Embryonic and Larval Development. International Journal of Molecular Sciences. 19(12)
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