Gene
ogdha
- ID
- ZDB-GENE-030131-2143
- Name
- oxoglutarate dehydrogenase a
- Symbol
- ogdha Nomenclature History
- Previous Names
-
- ogdh
- im:7045267
- wu:fa06d01
- wu:fb98a04
- zgc:73296
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity. Acts upstream of or within heart contraction. Predicted to be located in nucleus. Predicted to be part of oxoglutarate dehydrogenase complex. Predicted to be active in mitochondrion. Is expressed in several structures, including immature eye; lens; mesoderm; musculature system; and pronephric duct. Human ortholog(s) of this gene implicated in oxoglutarate dehydrogenase deficiency. Orthologous to human OGDH (oxoglutarate dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73296 (11 images)
- IMAGE:7146762 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026595Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa31676 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34482 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| oxoglutarate dehydrogenase deficiency | Alliance | Oxoglutarate dehydrogenase deficiency | 203740 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001017 | Dehydrogenase, E1 component |
| Domain | IPR005475 | Transketolase-like, pyrimidine-binding domain |
| Domain | IPR031717 | 2-oxoglutarate dehydrogenase E1 component/KDG, C-terminal |
| Domain | IPR032106 | 2-oxoglutarate dehydrogenase E1 component, N-terminal domain |
| Family | IPR011603 | 2-oxoglutarate dehydrogenase E1 component |
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Domain Details Per Protein
| Protein | Additional Resources | Length | 2-oxoglutarate dehydrogenase E1 component | 2-oxoglutarate dehydrogenase E1 component/KDG, C-terminal | 2-oxoglutarate dehydrogenase E1 component, N-terminal domain | Dehydrogenase, E1 component | Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily | Thiamin diphosphate-binding fold | Transketolase-like, pyrimidine-binding domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BJT5 | InterPro | 1054 | |||||||
| UniProtKB:B8JI08 | InterPro | 1022 | |||||||
| UniProtKB:F1Q5B8 | InterPro | 1019 | |||||||
| UniProtKB:A0A0R4IP01 | InterPro | 1022 | |||||||
| UniProtKB:A0A8M3AVG6 | InterPro | 1037 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-184L17 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-231K6 | ZFIN Curated Data | |
| Encodes | EST | fb98a04 | ||
| Encodes | EST | IMAGE:7045267 | ||
| Encodes | EST | IMAGE:7146762 | Thisse et al., 2004 | |
| Encodes | EST | wz7973 | ||
| Encodes | cDNA | MGC:73296 | ZFIN Curated Data | |
| Has Artifact | EST | fa06d01 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200779 (1) | 5184 nt | ||
| Genomic | GenBank:CU137648 (1) | 170704 nt | ||
| Polypeptide | UniProtKB:A0A8M2BJT5 (1) | 1054 aa |
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Lin, S.J., Vona, B., Lau, T., Huang, K., Zaki, M.S., Aldeen, H.S., Karimiani, E.G., Rocca, C., Noureldeen, M.M., Saad, A.K., Petree, C., Bartolomaeus, T., Abou Jamra, R., Zifarelli, G., Gotkhindikar, A., Wentzensen, I.M., Liao, M., Cork, E.E., Varshney, P., Hashemi, N., Mohammadi, M.H., Rad, A., Neira, J., Toosi, M.B., Knopp, C., Kurth, I., Challman, T.D., Smith, R., Abdalla, A., Haaf, T., Suri, M., Joshi, M., Chung, W.K., Moreno-De-Luca, A., Houlden, H., Maroofian, R., Varshney, G.K. (2023) Evaluating the association of biallelic OGDHL variants with significant phenotypic heterogeneity. Genome Medicine. 15:102102
- Lee, H.K., Kim, K., Lee, J., Lee, J., Lee, J., Kim, S., Lee, S.E., Kim, J.H. (2020) Targeted toxicometabolomics of endosulfan sulfate in adult zebrafish (Danio rerio) using GC-MS/MS in multiple reaction monitoring mode. Journal of hazardous materials. 389:122056
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Keßler, M., Berger, I.M., Just, S., Rottbauer, W. (2015) Loss of dihydrolipoyl succinyltransferase (DLST) leads to reduced resting heart rate in the zebrafish. Basic Research in Cardiology. 110:468
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Sato, Y., Hashiguchi, Y., and Nishida, M. (2009) Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. BMC Evolutionary Biology. 9:127
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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