Gene
actn3b
- ID
- ZDB-GENE-030131-2040
- Name
- actinin alpha 3b
- Symbol
- actn3b Nomenclature History
- Previous Names
-
- fb95c03
- wu:fb95c03
- wu:fc11d03
- zgc:77243 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization and muscle cell development. Predicted to be located in actin cytoskeleton. Predicted to be active in several cellular components, including Z disc; cell junction; and cortical actin cytoskeleton. Is expressed in several structures, including musculature system; ovary; pharyngeal arch 3-7; post-vent region; and segmental plate. Orthologous to human ACTN3 (actinin alpha 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hza101 | Allele with one deletion | Exon 24 | Unknown | CRISPR | |
| la016242Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa20858 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-actn3b,nup188 | Zebrafish Nomenclature Committee |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Actinin-type actin-binding domain, conserved site | Calponin homology domain | CH domain superfamily | EF-hand, Ca insensitive | EF-hand domain | EF-hand domain pair | Spectrin/alpha-actinin | Spectrin repeat |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q8AX99 | InterPro | 898 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
actn3b-201
(1)
|
Ensembl | 4,785 nt | ||
| mRNA |
actn3b-203
(1)
|
Ensembl | 6,222 nt | ||
| ncRNA |
actn3b-002
(1)
|
Ensembl | 432 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(myl7:actn3b-EGFP) |
|
| 1 | (18) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-184C11 | ZFIN Curated Data | |
| Contained in | BAC | CH211-258D20 | ||
| Encodes | EST | fb95c03 | ||
| Encodes | EST | fc11d03 | ||
| Encodes | cDNA | MGC:77243 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205544 (1) | 4785 nt | ||
| Genomic | GenBank:AL808019 (1) | 159698 nt | ||
| Polypeptide | UniProtKB:Q8AX99 (1) | 898 aa |
- Akerberg, A.A., Trembley, M., Butty, V., Schwertner, A., Zhao, L., Beerens, M., Liu, X., Mahamdeh, M., Yuan, S., Boyer, L., MacRae, C., Nguyen, C., Pu, W.T., Burns, C.E., Burns, C.G. (2022) RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function. Circulation research. 131(12):980-1000
- Zhang, X., Yang, Y., Wei, Y., Zhao, Q., Lou, X. (2022) Blf and drl cluster synergistically regulate cell fate commitment during zebrafish primitive hematopoiesis. Development (Cambridge, England). 149(24)
- Honkoop, H., Nguyen, P.D., van der Velden, V.E.M., Sonnen, K.F., Bakkers, J. (2021) Live imaging of adult zebrafish cardiomyocyte proliferation ex vivo. Development (Cambridge, England). 148(18):
- Metikala, S., Casie Chetty, S., Sumanas, S. (2021) Single-cell transcriptome analysis of the zebrafish embryonic trunk. PLoS One. 16:e0254024
- Peng, Y., Wang, W., Fang, Y., Hu, H., Chang, N., Pang, M., Hu, Y.F., Li, X., Long, H., Xiong, J.W., Zhang, R. (2021) Inhibition of TGF-β/Smad3 Signaling Disrupts Cardiomyocyte Cell Cycle Progression and Epithelial-Mesenchymal Transition-Like Response During Ventricle Regeneration. Frontiers in cell and developmental biology. 9:632372
- Beisaw, A., Kuenne, C., Günther, S., Dallmann, J., Wu, C.C., Bentsen, M., Looso, M., Stainier, D. (2020) AP-1 Contributes to Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion during Zebrafish Heart Regeneration. Circulation research. 126(12):1760-1778
- Carlantoni, C., Allanki, S., Kontarakis, Z., Rossi, A., Piesker, J., Günther, S., Stainier, D.Y.R. (2020) Tie1 regulates zebrafish cardiac morphogenesis through tolloid-like 1 expression. Developmental Biology. 469:54-67
- Demin, K.A., Lakstygal, A.M., Krotova, N.A., Masharsky, A., Tagawa, N., Chernysh, M.V., Ilyin, N.P., Taranov, A.S., Galstyan, D.S., Derzhavina, K.A., Levchenko, N.A., Kolesnikova, T.O., Mor, M.S., Vasyutina, M.L., Efimova, E.V., Katolikova, N., Prjibelski, A.D., Gainetdinov, R.R., de Abreu, M.S., Amstislavskaya, T.G., Strekalova, T., Kalueff, A.V. (2020) Understanding complex dynamics of behavioral, neurochemical and transcriptomic changes induced by prolonged chronic unpredictable stress in zebrafish. Scientific Reports. 10:19981
- Capasso, T.L., Li, B., Volek, H.J., Khalid, W., Rochon, E.R., Anbalagan, A., Herdman, C., Yost, H.J., Villanueva, F.S., Kim, K., Roman, B.L. (2019) BMP10-mediated ALK1 signaling is continuously required for vascular development and maintenance. Angiogenesis. 23(2):203-220
- Collins, M.M., Ahlberg, G., Hansen, C.V., Guenther, S., Marín-Juez, R., Sokol, A.M., El-Sammak, H., Piesker, J., Hellsten, Y., Olesen, M.S., Stainier, D.Y.R., Lundegaard, P.R. (2019) Early sarcomere and metabolic defects in a zebrafish pitx2c cardiac arrhythmia model. Proceedings of the National Academy of Sciences of the United States of America. 116(48):24115-24121
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