ZFIN is now using GRCz12tu for Genomic Data
Gene
atg7
- ID
- ZDB-GENE-030131-1633
- Name
- ATG7 autophagy related 7 homolog (S. cerevisiae)
- Symbol
- atg7 Nomenclature History
- Previous Names
-
- fb76g05
- im:7158252
- wu:fb76g05
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable Atg12 activating enzyme activity and Atg8 activating enzyme activity. Acts upstream of or within autophagosome assembly; heart development; and mitophagy. Predicted to be active in phagophore assembly site. Is expressed in several structures, including heart; liver; male organism; muscle; and retina. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 31. Orthologous to human ATG7 (autophagy related 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7158252 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hza54 | Allele with one deletion | Unknown | Frameshift | CRISPR | |
| hza55 | Allele with one deletion | Unknown | Frameshift | CRISPR | |
| sa10973 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa14235 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa14768 | Allele with one point mutation | Exon 15 | Premature Stop | ENU | |
| sa35001 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa41752 | Allele with one point mutation | Unknown | Unknown | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive spinocerebellar ataxia 31 | Alliance | Spinocerebellar ataxia, autosomal recessive 31 | 619422 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000594 | THIF-type NAD/FAD binding fold |
| Domain | IPR032197 | Ubiquitin-like modifier-activating enzyme Atg7, N-terminal |
| Family | IPR006285 | Ubiquitin-like modifier-activating enzyme Atg7 |
| Family | IPR045886 | ThiF/MoeB/HesA family |
| Homologous_superfamily | IPR042522 | Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 1 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ThiF/MoeB/HesA family | THIF-type NAD/FAD binding fold | Ubiquitin-like modifier-activating enzyme Atg7 | Ubiquitin-like modifier-activating enzyme Atg7, N-terminal | Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 1 | Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 2 |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QHT7 | InterPro | 704 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(actb2:LOXP-mCherry-LOXP-atg7-Cerulean) |
| 1 | Wang et al., 2021 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | EST | fb76g05 | ||
| Encodes | EST | IMAGE:7158252 | Thisse et al., 2004 |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_073916161 (1) | GRCz12tu | 3525 nt | |
| Genomic | GenBank:FO704634 (1) | 37522 nt | ||
| Polypeptide | UniProtKB:A0A8M9QHT7 (1) | 704 aa |
- Kelu, J.J., Hughes, S.M. (2025) Muscle peripheral circadian clock drives nocturnal protein degradation via raised Ror/Rev-erb balance and prevents premature sarcopenia. Proceedings of the National Academy of Sciences of the United States of America. 122:e2422446122e2422446122
- Li, Y., Shi, R., Xia, L., Zhang, X., Zhang, P., Liu, S., Liu, K., Sik, A., Stoika, R., Jin, M. (2025) Identification of Key Active Constituents in Eucommia ulmoides Oliv. Leaves Against Parkinson's Disease and the Alleviative Effects via 4E-BP1 Up-Regulation. International Journal of Molecular Sciences. 26:
- Ye, H., Li, D., Zhang, L., Wang, Y., Wang, C., Jin, M., Lin, H., Li, P., Sun, C., Li, N. (2025) Epicoccin A Ameliorates PD-like Symptoms in Zebrafish: Enhancement of PINK1/Parkin-Dependent Mitophagy and Inhibition of Excessive Oxidative Stress. Marine drugs. 23:
- Tucker, S.K., Gosul, R., Swartz, M.E., Zhang, S., Eberhart, J.K. (2024) Zebrafish raptor mutation inhibits the activity of mTORC1, inducing craniofacial defects due to autophagy-induced neural crest cell death. Development (Cambridge, England). 151(6):
- Zhu, P., Li, J., Yan, F., Islam, S., Lin, X., Xu, X. (2024) Allelic heterogeneity of TTNtv cardiomyopathy can be modeled in adult zebrafish. JCI insight. 9(7):
- Zhu, Y., Fujimaki, M., Snape, L., Lopez, A., Fleming, A., Rubinsztein, D.C. (2024) Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis. Nature cell biology. 26(4):542-551
- Wasilewska, I., Majewski, Ł., Adamek-Urbańska, D., Mondal, S.S., Baranykova, S., Gupta, R.K., Bielecki, D., Winata, C.L., Kuznicki, J. (2023) Lack of Stim2 Affects Vision-Dependent Behavior and Sensitivity to Hypoxia. Zebrafish. 20:146159146-159
- Zhu, Y., Hu, J., Zeng, S., Gao, M., Guo, S., Wang, M., Hong, Y., Zhao, G. (2023) L-selenomethionine affects liver development and glucolipid metabolism by inhibiting autophagy in zebrafish embryos. Ecotoxicology and environmental safety. 252:114589114589
- Kong, S., Zhou, D., Fan, Q., Zhao, T., Ren, C., Nie, H. (2022) Salviae miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection Protects against Myocardial Ischemia-Reperfusion Injury and Heart Failure. Computational and Mathematical Methods in Medicine. 2022:7809485
- Liu, S., Hu, G., Luo, S., Wu, W., Zhou, Q., Jin, R., Zhang, Y., Ruan, H., Huang, H., Li, H. (2022) Insights into the evolution of the ISG15 and UBA7 system. Genomics. 114(2):110302
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