Gene
cd9a
- ID
- ZDB-GENE-030131-1175
- Name
- CD9 molecule a
- Symbol
- cd9a Nomenclature History
- Previous Names
-
- cd9
- wu:fb61g04
- zgc:73383
- zgc:85743
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable integrin binding activity. Predicted to be involved in cell differentiation and nervous system development. Predicted to act upstream of or within cell adhesion. Predicted to be located in extracellular exosome and membrane. Predicted to be active in plasma membrane. Is expressed in cardiovascular system; liver; telencephalon; and visual system. Human ortholog(s) of this gene implicated in prostate adenocarcinoma. Orthologous to human CD9 (CD9 molecule).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73383 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb836 | Allele with one insertion | Exon 3 | Unknown | CRISPR | |
| ihb837 | Allele with one delins | Exon 3 | Unknown | CRISPR | |
| la020539Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa6498 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sh474 | Allele with one delins | Unknown | Unknown | CRISPR | |
| zf3825 | Allele with one delins | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cd9a | (2) | |
| CRISPR2-cd9a | Zebrafish Nomenclature Committee |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CD9, extracellular domain | Tetraspanin, animals | Tetraspanin, conserved site | Tetraspanin, EC2 domain superfamily | Tetraspanin/Peripherin |
|---|---|---|---|---|---|---|---|
| UniProtKB:E9QBC5 | InterPro | 228 | |||||
| UniProtKB:Q6NWG7 | InterPro | 227 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-89A11 | ZFIN Curated Data | |
| Encodes | EST | fb61g04 | ||
| Encodes | cDNA | MGC:73383 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:85743 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212619 (1) | 1173 nt | ||
| Genomic | GenBank:CU633973 (2) | 41627 nt | ||
| Polypeptide | UniProtKB:E9QBC5 (1) | 228 aa |
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Wang, D., Zheng, L., Cheng, B.Y.L., Sin, C.F., Li, R., Tsui, S.P., Yi, X., Ma, A.C.H., He, B.L., Leung, A.Y.H., Sun, X. (2023) Transgenic IDH2R172K and IDH2R140Q zebrafish models recapitulated features of human acute myeloid leukemia. Oncogene. 42(16):1272-1281
- Greaves, S., Marsay, K.S., Monk, P.N., Roehl, H., Partridge, L.J. (2022) Tetraspanin Cd9b plays a role in fertility in zebrafish. PLoS One. 17:e0277274
- Fujihara, Y., Herberg, S., Blaha, A., Panser, K., Kobayashi, K., Larasati, T., Novatchkova, M., Theussl, H.C., Olszanska, O., Ikawa, M., Pauli, A. (2021) The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization. Proceedings of the National Academy of Sciences of the United States of America. 118(39):
- Marsay, K.S., Greaves, S., Mahabaleshwar, H., Ho, C.M., Roehl, H., Monk, P.N., Carney, T.J., Partridge, L.J. (2021) Tetraspanin Cd9b and Cxcl12a/Cxcr4b have a synergistic effect on the control of collective cell migration. PLoS One. 16:e0260372
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Yang, D., Liu, Q., Yang, M., Wu, H., Wang, Q., Xiao, J., and Zhang, Y. (2012) RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish. BMC Genomics. 13(1):319
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