Gene
prkar2aa
- ID
- ZDB-GENE-030131-1007
- Name
- protein kinase, cAMP-dependent, regulatory, type II, alpha A
- Symbol
- prkar2aa Nomenclature History
- Previous Names
-
- wu:fb55f12
- wu:fj29e12
- wu:fj33e06
- zgc:153742
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable cAMP binding activity; cAMP-dependent protein kinase inhibitor activity; and protein kinase A catalytic subunit binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within phosphorylation and regulation of protein phosphorylation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of cAMP-dependent protein kinase complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018488 | Cyclic nucleotide-binding, conserved site |
| Domain | IPR000595 | Cyclic nucleotide-binding domain |
| Domain | IPR003117 | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain |
| Family | IPR012198 | cAMP-dependent protein kinase regulatory subunit |
| Family | IPR050503 | cAMP-dependent protein kinase regulatory subunit-like |
| Homologous_superfamily | IPR014710 | RmlC-like jelly roll fold |
| Homologous_superfamily | IPR018490 | Cyclic nucleotide-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | cAMP-dependent protein kinase regulatory subunit | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain | cAMP-dependent protein kinase regulatory subunit-like | Cyclic nucleotide-binding, conserved site | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | RmlC-like jelly roll fold |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A9C3T0 | InterPro | 397 | |||||||
| UniProtKB:Q08BH1 | InterPro | 397 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| antisense |
ottdart00000059334
(1)
|
Ensembl | 451 nt | ||
| mRNA |
prkar2aa-201
(1)
|
Ensembl | 3,514 nt |
Interactions and Pathways
No data available
Plasmids
No data available