Gene
coro1ca
- ID
- ZDB-GENE-030114-6
- Name
- coronin, actin binding protein, 1Ca
- Symbol
- coro1ca Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Involved in neural crest cell migration. Predicted to be located in endosome membrane. Is expressed in several structures, including digestive system; nervous system; neural tube; periderm; and solid lens vesicle. Orthologous to human CORO1C (coronin 1C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb655 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Williamson et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa11512 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa11685 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa14944 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa16635 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa33570 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa40394 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR019775 | WD40 repeat, conserved site |
Domain | IPR015048 | Domain of unknown function DUF1899 |
Family | IPR015505 | Coronin |
Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Coronin | Domain of unknown function DUF1899 | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
---|---|---|---|---|---|---|---|---|
UniProtKB:B0R0D7 | InterPro | 474 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
coro1ca-201
(1)
|
Ensembl | 5,204 nt | ||
mRNA |
coro1ca-202
(1)
|
Ensembl | 1,455 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-108C6 | ||
Contained in | BAC | CH211-191D15 | ||
Encodes | EST | cb655 | Thisse et al., 2001 | |
Encodes | EST | fa99e02 | ZFIN Curated Data | |
Encodes | EST | fb30g03 | ZFIN Curated Data | |
Encodes | EST | fc60a02 | ||
Encodes | EST | fi35a01 | ||
Encodes | cDNA | MGC:55437 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192833 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_201295 (1) | 2150 nt | ||
Genomic | GenBank:AL845302 (2) | 147219 nt | ||
Polypeptide | UniProtKB:B0R0D7 (1) | 474 aa |
- Lumley, A.I., Zhang, L., Ernens, I., Leszek, P., Devaux, Y. (2020) The long non-coding RNA landscape of cardiac regeneration in zebrafish. The Canadian journal of cardiology. 37(3):484-492
- Beaudoin, J.D., Novoa, E.M., Vejnar, C.E., Yartseva, V., Takacs, C.M., Kellis, M., Giraldez, A.J. (2018) Analyses of mRNA structure dynamics identify embryonic gene regulatory programs. Nature structural & molecular biology. 25(8):677-686
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Williamson, R.C., Cowell, C.A., Hammond, C.L., Bergen, D., Roper, J., Feng, Y., Rendall, T.C., Race, P.R., Bass, M.D. (2014) Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure. Journal of Cell Science. 127(Pt 19):4292-307
- Mishima, Y., Abreu-Goodger, C., Staton, A.A., Stahlhut, C., Shou, C., Cheng, C., Gerstein, M., Enright, A.J., and Giraldez, A.J. (2009) Zebrafish miR-1 and miR-133 shape muscle gene expression and regulate sarcomeric actin organization. Genes & Development. 23(5):619-632
- Xavier, C.P., Eichinger, L., Fernandez, M.P., Morgan, R.O., and Clemen, C.S. (2008) Evolutionary and functional diversity of coronin proteins. Sub-cellular biochemistry. 48:98-109
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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