Gene

farsb

ID
ZDB-GENE-021206-2
Name
phenylalanyl-tRNA synthetase subunit beta
Symbol
farsb Nomenclature History
Previous Names
  • farsl
  • cb428 (1)
  • zgc:92055
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to enable several functions, including ATP binding activity; aminoacyl-tRNA ligase activity; and magnesium ion binding activity. Predicted to contribute to phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Predicted to be located in cytoplasm. Predicted to be part of phenylalanine-tRNA ligase complex. Is expressed in several structures, including alar plate midbrain region; digestive system; immature eye; musculature system; and nervous system. Orthologous to human FARSB (phenylalanyl-tRNA synthetase subunit beta).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2001
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la027652TgTransgenic insertionUnknownUnknownDNA
y307EtTransgenic insertionUnknownUnknownDNA
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Sequence Targeting Reagents
No data available
Human Disease
Associated With farsb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Rajab interstitial lung disease with brain calcifications 1 613658
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Associated With farsb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR005146 B3/B4 tRNA-binding domain
Domain IPR005147 tRNA synthetase, B5-domain
Domain IPR040659 Phenylalanine--tRNA ligase beta subunit, B1 domain
Domain IPR041616 Phenylalanyl tRNA synthetase beta chain, core domain
Family IPR004531 Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archaeal/eukaryotic type
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Domain Details Per Protein
Protein Additional Resources Length B3/B4 tRNA-binding domain Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) Phenylalanine--tRNA ligase beta subunit, B1 domain Phenylalanine-tRNA ligase, class IIc, beta subunit Phenylalanyl tRNA synthetase beta chain, core domain Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archaeal/eukaryotic type Phenylalanyl-tRNA synthetase-like, B3/B4 Putative DNA-binding domain superfamily tRNA synthetase, B5-domain
UniProtKB:Q5RKM6 InterPro 590
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 15
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA farsb-201 (1) Ensembl 2,052 nt
ncRNA farsb-002 (1) Ensembl 939 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-245G11ZFIN Curated Data
EncodesESTcb428Thisse et al., 2001
EncodescDNAMGC:92055ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanFARSB2
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseFarsb1
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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