Gene

c7b

ID
ZDB-GENE-021120-1
Name
complement component 7b
Symbol
c7b Nomenclature History
Previous Names
  • c7 (1)
  • C7-1 (1)
  • cb349 (1)
  • si:dkey-246j23.5
  • wu:fa01f03
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to be involved in complement activation. Predicted to localize to membrane attack complex. Human ortholog(s) of this gene implicated in complement component 7 deficiency. Is expressed in central nervous system and yolk syncytial layer. Orthologous to human C7 (complement C7).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With c7b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
complement component 7 deficiency Alliance C7 deficiency 610102
Associated With c7b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020863 Membrane attack complex component/perforin domain, conserved site
Domain IPR000436 Sushi/SCR/CCP domain
Domain IPR003884 Factor I / membrane attack complex
Domain IPR020864 Membrane attack complex component/perforin (MACPF) domain
Domain IPR040729 Kazal-type serine protease inhibitor domain
Family IPR001862 Membrane attack complex component/perforin/complement C9
Homologous_superfamily IPR035976 Sushi/SCR/CCP superfamily
Homologous_superfamily IPR036055 LDL receptor-like superfamily
Homologous_superfamily IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
Repeat IPR000884 Thrombospondin type-1 (TSP1) repeat
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Domain Details Per Protein
Protein Length Factor I / membrane attack complex Kazal-type serine protease inhibitor domain LDL receptor-like superfamily Low-density lipoprotein (LDL) receptor class A repeat Membrane attack complex component/perforin/complement C9 Membrane attack complex component/perforin domain, conserved site Membrane attack complex component/perforin (MACPF) domain Sushi/SCR/CCP domain Sushi/SCR/CCP superfamily Thrombospondin type-1 (TSP1) repeat Thrombospondin type-1 (TSP1) repeat superfamily
UniProtKB:A0A8M9PWA7 833
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations