Gene
has3
- ID
- ZDB-GENE-021118-1
- Name
- hyaluronan synthase 3
- Symbol
- has3 Nomenclature History
- Previous Names
-
- af190743gs2
- xx:af190743gs1
- xx:af190743gs2
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable hyaluronan synthase activity. Predicted to be involved in extracellular matrix assembly; hyaluronan biosynthetic process; and polysaccharide biosynthetic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in hypochord; median fin fold; nervous system; otic vesicle; and pectoral fin. Orthologous to human HAS3 (hyaluronan synthase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu897 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ouyang et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Homologous_superfamily | IPR029044 | Nucleotide-diphospho-sugar transferases |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleotide-diphospho-sugar transferases |
|---|---|---|---|
| UniProtKB:Q1LUE8 | InterPro | 555 | |
| UniProtKB:A0A8M3AJI3 | InterPro | 558 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-218C6 | ZFIN Curated Data | |
| Encodes | EST | af190743gs1 | ||
| Encodes | EST | af190743gs2 | ||
| Encodes | EST | eu897 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:194846 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_173220 (1) | 1763 nt | ||
| Genomic | GenBank:BX323598 (1) | 197329 nt | ||
| Polypeptide | UniProtKB:A0A8M3AJI3 (1) | 558 aa |
- Mori, Y., Smith, S., Wang, J., Eliora, N., Heikes, K.L., Munjal, A. (2024) Versican controlled by Lmx1b regulates hyaluronate density and hydration for semicircular canal morphogenesis. Development (Cambridge, England). 152(1):
- Ren, M., Chen, X., Dai, L., Tu, J., Hu, H., Sun, X., Luo, J., Li, P., Fu, Y., Zhu, Y., Sun, W., Tang, Z., Liu, M., Ren, X., Lu, Q. (2024) Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish. Biomedicines. 13:
- Ezhkova, D., Schwarzer, S., Spieß, S., Geffarth, M., Machate, A., Zöller, D., Stucke, J., Alexopoulou, D., Lesche, M., Dahl, A., Hans, S. (2023) Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish. Biology Open. 12(6):
- Mackowetzky, K., Dicipulo, R., Fox, S.C., Philibert, D.A., Todesco, H., Doshi, J.D., Kawakami, K., Tierney, K., Waskiewicz, A.J. (2022) Retinoic Acid Signaling Regulates Late Stages of Semicircular Canal Morphogenesis and Otolith Maintenance in the Zebrafish Inner Ear. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(11):1798-1815
- Munjal, A., Hannezo, E., Tsai, T.Y., Mitchison, T.J., Megason, S.G. (2021) Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis. Cell. 184:6313-6325.e18
- Ouyang, X., Panetta, N.J., Talbott, M.D., Payumo, A.Y., Halluin, C., Longaker, M.T., Chen, J.K. (2017) Hyaluronic acid synthesis is required for zebrafish tail fin regeneration. PLoS One. 12:e0171898
- Askary, A., Smeeton, J., Paul, S., Schindler, S., Braasch, I., Ellis, N.A., Postlethwait, J., Miller, C.T., Crump, J.G. (2016) Ancient origin of lubricated joints in bony vertebrates. eLIFE. 5
- Govindan, J., Tun, K.M., Iovine, M.K. (2016) Cx43-Dependent Skeletal Phenotypes Are Mediated by Interactions between the Hapln1a-ECM and Sema3d during Fin Regeneration. PLoS One. 11:e0148202
- Missinato, M.A., Tobita, K., Romano, N., Carroll, J.A., Tsang, M. (2015) Extracellular component hyaluronic acid and its receptor Hmmr are required for epicardial EMT during heart regeneration. Cardiovascular research. 107(4):487-98
- Geng, F.S., Abbas, L., Baxendale, S., Holdsworth, C.J., Swanson, A.G., Slanchev, K., Hammerschmidt, M., Topczewski, J., and Whitfield, T.T. (2013) Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene. Development (Cambridge, England). 40(21):4362-4374
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