ZFIN is now using GRCz12tu for Genomic Data
Gene
trpm7
- ID
- ZDB-GENE-021115-2
- Name
- transient receptor potential cation channel, subfamily M, member 7
- Symbol
- trpm7 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable calcium channel activity. Acts upstream of or within several processes, including exocrine pancreas development; magnesium ion homeostasis; and melanocyte differentiation. Located in plasma membrane. Is expressed in several structures, including digestive system; immature eye; integument; nervous system; and renal system. Used to study sinoatrial node disease. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1. Orthologous to human TRPM7 (transient receptor potential cation channel subfamily M member 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 57 figures from 32 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb495 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- 34 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 | Alliance | {Amyotrophic lateral sclerosis-parkinsonism/dementia complex, susceptibility to} | 105500 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| sinoatrial node disease | WT + MO3-trpm7 | standard conditions | Sah et al., 2013 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004166 | Alpha-type protein kinase, alpha-kinase domain |
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR029601 | Transient receptor potential cation channel subfamily M member 7, alpha-kinase domain |
| Domain | IPR032415 | TRPM, tetramerisation domain |
| Domain | IPR041491 | TRPM, SLOG domain |
| Family | IPR050927 | Transient receptor potential cation channel M |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR037162 | TRPM, tetramerisation domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha-type protein kinase, alpha-kinase domain | Ion transport domain | Protein kinase-like domain superfamily | Transient receptor potential cation channel M | Transient receptor potential cation channel subfamily M member 7, alpha-kinase domain | TRPM, SLOG domain | TRPM, tetramerisation domain | TRPM, tetramerisation domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q563W7 | InterPro | 1774 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers