Gene

cad

ID
ZDB-GENE-021030-4
Name
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Symbol
cad Nomenclature History
Previous Names
  • cb456 (1)
  • si:dkey-221h15.3
  • wu:fc30c12
  • wu:fc33d01
  • wu:fc67g02 (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to contribute to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; cranial nerve morphogenesis; and regulation of signal transduction. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 50. Is expressed in several structures, including digestive system; immature eye; nervous system; neural tube; and pectoral fin. Orthologous to human CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cad Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
developmental and epileptic encephalopathy 50 Alliance Developmental and epileptic encephalopathy 50 616457
Associated With cad Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR002195 Dihydroorotase, conserved site
Domain IPR002474 Carbamoyl-phosphate synthase small subunit, N-terminal domain
Domain IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
Domain IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain
Domain IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain
Domain IPR006131 Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain
Domain IPR006132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding
Domain IPR006680 Amidohydrolase-related
Domain IPR011607 Methylglyoxal synthase-like domain
Domain IPR011761 ATP-grasp fold
Domain IPR017926 Glutamine amidotransferase
Domain IPR035686 Carbamoyl-phosphate synthase small subunit, GATase1 domain
Family IPR002082 Aspartate carbamoyltransferase
Family IPR006130 Aspartate/ornithine carbamoyltransferase
Family IPR006274 Carbamoyl-phosphate synthase, small subunit
Family IPR006275 Carbamoyl-phosphate synthase, large subunit
Homologous_superfamily IPR011059 Metal-dependent hydrolase, composite domain superfamily
Homologous_superfamily IPR013815 ATP-grasp fold, subdomain 1
Homologous_superfamily IPR016185 Pre-ATP-grasp domain superfamily
Homologous_superfamily IPR029062 Class I glutamine amidotransferase-like
Homologous_superfamily IPR032466 Metal-dependent hydrolase
Homologous_superfamily IPR036480 Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily
Homologous_superfamily IPR036897 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily
Homologous_superfamily IPR036901 Aspartate/ornithine carbamoyltransferase superfamily
Homologous_superfamily IPR036914 Methylglyoxal synthase-like domain superfamily
Domain Details Per Protein
Protein Length Amidohydrolase-related Aspartate carbamoyltransferase Aspartate/ornithine carbamoyltransferase Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding Aspartate/ornithine carbamoyltransferase superfamily ATP-grasp fold ATP-grasp fold, subdomain 1 Carbamoyl-phosphate synthase, large subunit Carbamoyl-phosphate synthase large subunit, CPSase domain Carbamoyl-phosphate synthase, small subunit Carbamoyl-phosphate synthase small subunit, GATase1 domain Carbamoyl-phosphate synthase small subunit, N-terminal domain Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain Carbamoyl-phosphate synthetase, large subunit oligomerisation domain Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily Class I glutamine amidotransferase-like Dihydroorotase, conserved site Glutamine amidotransferase Metal-dependent hydrolase Metal-dependent hydrolase, composite domain superfamily Methylglyoxal synthase-like domain Methylglyoxal synthase-like domain superfamily Pre-ATP-grasp domain superfamily
UniProtKB:Q5XLV0 2230
UniProtKB:F1Q9V4 485
UniProtKB:Q5EI67 2226
UniProtKB:U3JAV8 2230
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations