Gene
tlx3b
- ID
- ZDB-GENE-021021-1
- Name
- T cell leukemia homeobox 3b
- Symbol
- tlx3b Nomenclature History
- Previous Names
-
- tlx3
- ztlx-3b (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in animal organ development and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in cranial ganglion; neurons; and trigeminal placode. Orthologous to human TLX3 (T cell leukemia homeobox 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa | T-cell leukemia homeobox protein 1/2/3 |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q8JI11 | InterPro | 300 | |||||
| UniProtKB:A0A8M1PA75 | InterPro | 300 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-4C2 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193918 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193956 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_170766 (1) | 2281 nt | ||
| Genomic | GenBank:BX005027 (1) | 241472 nt | ||
| Polypeptide | UniProtKB:A0A8M1PA75 (1) | 300 aa |
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Sundaramoorthi, H., Fallatah, W., Mary, J., Jagadeeswaran, P. (2023) Discovery of seven hox genes in zebrafish thrombopoiesis. Blood cells, molecules & diseases. 104:102796102796
- Schwarzer, S., Spieß, S., Brand, M., Hans, S. (2017) Dlx3b/4b is required for early-born but not later-forming sensory hair cells during zebrafish inner ear development. Biology Open. 6(9):1270-1278
- Takeuchi, M., Yamaguchi, S., Sakakibara, M., Hayashi, T., Matsuda, K., Hara, Y., Tanegashima, C., Shimizu, T., Kuraku, S., Hibi, M. (2017) Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. The Journal of comparative neurology. 525(7):1558-1585
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Aoki, M., Segawa, H., Naito, M., and Okamoto, H. (2014) Identification of possible downstream genes required for the extension of peripheral axons in primary sensory neurons. Biochemical and Biophysical Research Communications. 445(2):357-362
- Hans, S., Irmscher, A., and Brand, M. (2013) Zebrafish Foxi1 provides a neuronal ground state during inner ear induction preceding the Dlx3b/4b-regulated sensory lineage. Development (Cambridge, England). 140(9):1936-1945
- Regadas, I., Matos, M.R., Monteiro, F.A., Gomez-Skarmeta, J.L., Lima, D., Bessa, J., Casares, F., and Reguenga, C. (2013) Several Cis-regulatory Elements Control mRNA Stability, Translation Efficiency, and Expression Pattern of Prrxl1 (Paired Related Homeobox Protein-like 1). The Journal of biological chemistry. 288(51):36285-301
- Blackburn, J.S., Liu, S., Raiser, D.M., Martinez, S.A., Feng, H., Meeker, N.D., Gentry, J., Neuberg, D., Look, A.T., Ramaswamy, S., Bernards, A., Trede, N.S., and Langenau, D.M. (2012) Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency. Leukemia. 26(9):2069-2078
- Jovelin, R., Yan, Y.L., He, X., Catchen, J., Amores, A., Canestro, C., Yokoi, H., and Postlethwait, J.H. (2010) Evolution of developmental regulation in the vertebrate FgfD subfamily. Journal of experimental zoology. Part B, Molecular and developmental evolution. 314(1):33-56
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