Gene

stt3a

ID

ZDB-GENE-021015-3

Name

STT3 oligosaccharyltransferase complex catalytic subunit A

Symbol

stt3a Nomenclature History

Previous Names

cb437 (1)
itm1
wu:fb38c11

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to have dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in post-translational protein modification and protein N-linked glycosylation via asparagine. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iw. Is expressed in axial mesoderm; hatching gland; musculature system; notochord; and otic placode. Orthologous to human STT3A (STT3 oligosaccharyltransferase complex catalytic subunit A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb437 (12 images)
IMAGE:7143563 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With stt3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital disorder of glycosylation Iw	Alliance	Congenital disorder of glycosylation, type Iw, autosomal recessive	615596
		Congenital disorder of glycosylation, type Iw, autosomal dominant	619714

Associated With stt3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR048307	Oligosaccharyl transferase STT3, N-terminal domain
Domain	IPR048999	STT3/PglB/AglB, core domain
Family	IPR003674	Oligosaccharyl transferase, STT3 subunit