Gene
tram1
- ID
- ZDB-GENE-021011-1
- Name
- translocation associated membrane protein 1
- Symbol
- tram1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Acts upstream of or within determination of heart left/right asymmetry. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including anterior axial hypoblast; axial mesoderm; axis; digestive system; and hatching gland. Orthologous to several human genes including TRAM1 (translocation associated membrane protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb289 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Shim et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la022849Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa37843 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | TRAM/LAG1/CLN8 homology domain | Translocation associated membrane protein |
---|---|---|---|---|
UniProtKB:Q6P4U7 | InterPro | 369 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-19O24 | ZFIN Curated Data | |
Contained in | BAC | DKEY-237J21 | ZFIN Curated Data | |
Encodes | EST | cb289 | Thisse et al., 2001 | |
Encodes | EST | fc67b03 | ZFIN Curated Data | |
Encodes | EST | fi09h09 | ZFIN Curated Data | |
Encodes | cDNA | MGC:56707 | ZFIN Curated Data | |
Encodes | cDNA | MGC:77821 | ZFIN Curated Data | |
Has Artifact | EST | fb67f10 |
1 - 8 of 8
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_153669 (1) | 2239 nt | ||
Genomic | GenBank:BX510326 (1) | 239398 nt | ||
Polypeptide | UniProtKB:Q6P4U7 (1) | 369 aa |
- Kawaguchi, M., Sugiyama, K., Matsubara, K., Lin, C.Y., Kuraku, S., Hashimoto, S., Suwa, Y., Yong, L.W., Takino, K., Higashida, S., Kawamura, D., Yu, J.K., Seki, Y. (2019) Co-option of the PRDM14-CBFA2T complex from motor neurons to pluripotent cells during vertebrate evolution. Development (Cambridge, England). 146(2):
- Shim, J.E., Kim, J.H., Shin, J., Lee, J.E., Lee, I. (2019) Pathway-specific protein domains are predictive for human diseases. PLoS Computational Biology. 15:e1007052
- Pashay Ahi, E., Walker, B.S., Lassiter, C.S., Jónsson, Z.O. (2016) Investigation of the effects of estrogen on skeletal gene expression during zebrafish larval head development. PeerJ. 4:e1878
- Jheng, Y.H., Lee, L.H., Ting, C.H., Pan, C.Y., Hui, C.F., Chen, J.Y. (2015) Zebrafish fed on recombinant Artemia expressing epinecidin-1 exhibit increased survival and altered expression of immunomodulatory genes upon Vibrio vulnificus infection. Fish & shellfish immunology. 42:1-15
- Wang, Y.D., Peng, K.C., Wu, J.L., Chen, J.Y. (2014) Transgenic expression of salmon delta-5 and delta-6 desaturase in zebrafish muscle inhibits the growth of Vibrio alginolyticus and affects fish immunomodulatory activity. Fish & shellfish immunology. 39(2):223-30
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Pan, C.Y., Peng, K.C., Lin, C.H., and Chen, J.Y. (2011) Transgenic expression of tilapia hepcidin 1-5 and shrimp chelonianin in zebrafish and their resistance to bacterial pathogens. Fish & shellfish immunology. 31(2):275-85
- Hsieh, J.C., Pan, C.Y., and Chen, J.Y. (2010) Tilapia hepcidin (TH)2-3 as a transgene in transgenic fish enhances resistance to Vibrio vulnificus infection and causes variations in immune-related genes after infection by different bacterial species. Fish & shellfish immunology. 29(3):430-439
- Lindeman, L.C., Reiner, A.H., Mathavan, S., Aleström, P., and Collas, P. (2010) Tiling histone h3 lysine 4 and 27 methylation in zebrafish using high-density microarrays. PLoS One. 5(12):e15651
- Peng, K.C., Pan, C.Y., Chou, H.N., and Chen, J.Y. (2010) Using an improved Tol2 transposon system to produce transgenic zebrafish with epinecidin-1 which enhanced resistance to bacterial infection. Fish & shellfish immunology. 28(5-6):905-917
1 - 10 of 15
Show