Gene

esr1

ID
ZDB-GENE-020806-5
Name
estrogen receptor 1
Symbol
esr1 Nomenclature History
Previous Names
  • ER[a] (1)
  • ERalpha (1)
  • NR3A1 (1)
  • zfER[a] (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Exhibits estrogen receptor activity; nuclear receptor activity; and steroid hormone binding activity. Involved in several processes, including cellular response to estrogen stimulus; posterior lateral line neuromast primordium migration; and response to estradiol. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast cancer (multiple); rheumatic disease (multiple); and type 2 diabetes mellitus. Is expressed in several structures, including diencephalon; head; liver; male organism; and pleuroperitoneal region. Orthologous to human ESR1 (estrogen receptor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
44 figures from 27 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
12 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With esr1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
breast cancer Alliance Breast cancer, somatic 114480
migraine Alliance {Migraine, susceptibility to} 157300
Estrogen resistance 615363
{Myocardial infarction, susceptibility to} 608446
Associated With esr1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Family IPR001292 Oestrogen receptor
Family IPR001723 Nuclear hormone receptor
Family IPR024178 Oestrogen receptor/oestrogen-related receptor
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Oestrogen receptor Oestrogen receptor/oestrogen-related receptor Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:B4XRZ3 621
UniProtKB:B3DGP1 569
UniProtKB:A0A0R4ID06 18
UniProtKB:Q9I984 276
UniProtKB:A5PMH3 569
UniProtKB:E5G0W6 93
UniProtKB:F1QL15 505
UniProtKB:J9XWH0 18
UniProtKB:B4XRZ4 505
UniProtKB:P57717 569
UniProtKB:U3Q5I8 79
UniProtKB:A0A2R8QHN3 623
UniProtKB:E5G0W5 21
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations