Gene
gstp1.2
- ID
- ZDB-GENE-020806-4
- Name
- glutathione S-transferase pi 1.2
- Symbol
- gstp1.2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Enables glutathione transferase activity. Acts upstream of or within cellular response to xenobiotic stimulus. Predicted to be located in mitochondrion and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including digestive system; endoderm; pleuroperitoneal region; sensory system; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); carcinoma (multiple); hematologic cancer (multiple); reproductive organ cancer (multiple); and respiratory system disease (multiple). Orthologous to human GSTP1 (glutathione S-transferase pi 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 59 figures from 38 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb356 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Zhang et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024573Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| muz301 | Allele with one deletion | Exon 3 | Premature Stop | CRISPR | |
| w235 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gstp1.2 | (2) | |
| CRISPR2-gstp1.2 | (2) | |
| CRISPR3-gstp1.2 | Zhang et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004045 | Glutathione S-transferase, N-terminal |
| Domain | IPR004046 | Glutathione S-transferase, C-terminal |
| Domain | IPR010987 | Glutathione S-transferase, C-terminal-like |
| Family | IPR003082 | Glutathione S-transferase, Pi class |
| Family | IPR040079 | Glutathione transferase family |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Glutathione S-transferase, C-terminal | Glutathione S-transferase, C-terminal domain superfamily | Glutathione S-transferase, C-terminal-like | Glutathione S-transferase, N-terminal | Glutathione S-transferase, Pi class | Glutathione S-transferase superfamily | Glutathione transferase family | Thioredoxin-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9DDU5 | InterPro | 208 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-3.5gstp1.2:EGFP) |
|
| 2 | (7) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-370D1 | ZFIN Curated Data | |
| Encodes | EST | cb356 | Thisse et al., 2001 | |
| Encodes | EST | fa02f07 | ||
| Encodes | EST | fj23a02 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103706 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194005 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194036 | ZFIN Curated Data | |
| Has Artifact | EST | fb09d09 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131734 (1) | 914 nt | ||
| Genomic | GenBank:FP102983 (1) | 91094 nt | ||
| Polypeptide | UniProtKB:Q9DDU5 (1) | 208 aa |