Gene

tbx18

ID
ZDB-GENE-020529-2
Name
T-box transcription factor 18
Symbol
tbx18 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including morphogenesis of embryonic epithelium; regulation of transcription by RNA polymerase II; and somitogenesis. Predicted to act upstream of or within positive regulation of DNA-templated transcription. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including fin bud; medial longitudinal fasciculus; pectoral fin; pericardial region; and proepicardial cluster. Human ortholog(s) of this gene implicated in CAKUT2. Orthologous to human TBX18 (T-box transcription factor 18).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
41 figures from 21 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tbx18 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
CAKUT2 Alliance Congenital anomalies of kidney and urinary tract 2 143400
1 - 1 of 1
Associated With tbx18 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018186 Transcription factor, T-box, conserved site
Domain IPR046360 T-box transcription factor, DNA-binding domain
Family IPR001699 T-box transcription factor
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily IPR036960 T-box superfamily
1 - 5 of 5
Domain Details Per Protein
Protein Additional Resources Length p53-like transcription factor, DNA-binding domain superfamily T-box superfamily T-box transcription factor T-box transcription factor, DNA-binding domain Transcription factor, T-box, conserved site
UniProtKB:Q8JFF9 InterPro 554
UniProtKB:A0A8M1PA62 InterPro 554
1 - 2 of 2
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA tbx18-201 (1)
Ensembl
Ensembl 2,333 nt
ZFIN BLAST
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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