Gene

tpi1b

ID

ZDB-GENE-020416-4

Name

triosephosphate isomerase 1b

Symbol

tpi1b Nomenclature History

Previous Names

cb179 (1)
DrTPI-B (1)
wu:fb51c02

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have methylglyoxal synthase activity; protein homodimerization activity; and triose-phosphate isomerase activity. Predicted to be involved in several processes, including gluconeogenesis; glyceraldehyde-3-phosphate biosynthetic process; and methylglyoxal biosynthetic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Is expressed in several structures, including brain; cardiovascular system; mesoderm; musculature system; and pleuroperitoneal region. Orthologous to human TPI1 (triosephosphate isomerase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb179 (13 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tpi1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
triosephosphate isomerase deficiency	Alliance	Hemolytic anemia due to triosephosphate isomerase deficiency	615512

Associated With tpi1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR020861	Triosephosphate isomerase, active site
Family	IPR000652	Triosephosphate isomerase
Family	IPR022896	Triosephosphate isomerase, bacterial/eukaryotic
Homologous_superfamily	IPR013785	Aldolase-type TIM barrel
Homologous_superfamily	IPR035990	Triosephosphate isomerase superfamily

Domain Details Per Protein

Protein	Length	Aldolase-type TIM barrel	Triosephosphate isomerase	Triosephosphate isomerase, active site	Triosephosphate isomerase, bacterial/eukaryotic	Triosephosphate isomerase superfamily
UniProtKB:A0A0R4IGG3 InterPro	248
UniProtKB:Q90XG0 InterPro	248

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tpi1b-201 (1) Ensembl	Havana	1348 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpi1b-202 (1) Ensembl	Havana	720 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	tpi1b-003 (1) Ensembl	Havana	758 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	tpi1b-004 (1) Ensembl	Havana	525 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations