Gene
gria1b
- ID
- ZDB-GENE-020125-2
- Name
- glutamate receptor, ionotropic, AMPA 1b
- Symbol
- gria1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable AMPA glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in postsynaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in dendritic spine and postsynaptic density membrane. Is expressed in nervous system and otic vesicle. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 67; autosomal recessive intellectual developmental disorder 76; and epilepsy. Orthologous to human GRIA1 (glutamate ionotropic receptor AMPA type subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu293 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a376 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| a377 | Allele with one delins | Unknown | Unknown | CRISPR | |
| la021920Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa39331 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gria1b | Thyme et al., 2019 | |
| CRISPR2-gria1b | Thyme et al., 2019 | |
| CRISPR3-gria1b | Thyme et al., 2019 | |
| CRISPR4-gria1b | Thyme et al., 2019 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 67 | Alliance | Intellectual developmental disorder, autosomal dominant 67 | 619927 |
| autosomal recessive intellectual developmental disorder 76 | Alliance | ?Intellectual developmental disorder, autosomal recessive 76 | 619931 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001320 | Ionotropic glutamate receptor, C-terminal |
| Domain | IPR001828 | Receptor, ligand binding region |
| Domain | IPR019594 | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain |
| Family | IPR015683 | Ionotropic glutamate receptor |
| Homologous_superfamily | IPR028082 | Periplasmic binding protein-like I |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Ionotropic glutamate receptor | Ionotropic glutamate receptor, C-terminal | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain | Periplasmic binding protein-like I | Receptor, ligand binding region |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q71E64 | InterPro | 917 | |||||
| UniProtKB:F1RE87 | InterPro | ||||||
| UniProtKB:E7F1V8 | InterPro | 917 | |||||
| UniProtKB:A0A8M3AU00 | InterPro | 831 | |||||
| UniProtKB:A0AB32TD97 | InterPro | 825 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
gria1b-203
(1)
|
Ensembl | 992 nt | ||
| mRNA |
gria1b-201
(1)
|
Ensembl | 3,816 nt | ||
| mRNA |
gria1b-202
(1)
|
Ensembl | 3,515 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-42G2 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-192M20 | ZFIN Curated Data | |
| Encodes | EST | eu293 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:193652 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205730 (1) | 3820 nt | ||
| Genomic | GenBank:BX890629 (2) | 169168 nt | ||
| Polypeptide | UniProtKB:E7F1V8 (2) | 917 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | GRIA1 | 5 | Amino acid sequence comparison (2) |
- Li, J., Zhou, Z., Feng, F., Yuan, W., Zhang, Y., Wang, J., Zhang, B., Jin, H., He, S., Ding, L. (2025) Three New α-Pyrone Derivatives with Antiepileptic Activity from the Marine Actinomycete Nocardiopsis sp. NBUDK19. Marine biotechnology (New York, N.Y.). 27:8585
- Ikeda, A., Yamasaki, C., Kubo, Y., Doi, Y., Komamizu, M., Komatsu, M., Shiozaki, K. (2022) Alteration of the neuronal and glial cell profiles in Neu1-deficient zebrafish. Glycoconjugate journal. 39(4):499-512
- Bian, Y., Wang, X., Liang, J.H., Li, L., Wu, X., Tang, B., Leung, G.P., Lee, S.M. (2021) The development of behavioral sensitization induced by a single morphine exposure in adult zebrafish (Danio rerio). Progress in neuro-psychopharmacology & biological psychiatry. 113:110456
- Liu, C., Wang, Y., Deng, J., Lin, J., Hu, C., Li, Q., Xu, X. (2021) Social Deficits and Repetitive Behaviors Are Improved by Early Postnatal Low-Dose VPA Intervention in a Novel shank3-Deficient Zebrafish Model. Frontiers in neuroscience. 15:682054
- Okamoto, H., Cherng, B.W., Nakajo, H., Chou, M.Y., Kinoshita, M. (2021) Habenula as the experience-dependent controlling switchboard of behavior and attention in social conflict and learning. Current opinion in neurobiology. 68:36-43
- Piller, M., Werkman, I.L., Brown, E.A., Latimer, A.J., Kucenas, S. (2021) Glutamate signaling via the AMPAR subunit GluR4 regulates oligodendrocyte progenitor cell migration in the developing spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(25):5353-5371
- Wang, X., Liao, Q., Chen, H., Gong, G., Siu, S.W.I., Chen, Q., Kam, H., Ung, C.O.L., Cheung, K.K., Rádis-Baptista, G., Wong, C.T.T., Lee, S.M. (2021) Toxic Peptide From Palythoa caribaeorum Acting on the TRPV1 Channel Prevents Pentylenetetrazol-Induced Epilepsy in Zebrafish Larvae. Frontiers in pharmacology. 12:763089
- Maugars, G., Nourizadeh-Lillabadi, R., Weltzien, F.A. (2020) New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. Frontiers in endocrinology. 11:538196
- Naderi, M., Salahinejad, A., Attaran, A., Chivers, D.P., Niyogi, S. (2020) Chronic exposure to environmentally relevant concentrations of bisphenol S differentially affects cognitive behaviors in adult female zebrafish. Environmental pollution (Barking, Essex : 1987). 261:114060
- Naderi, M., Salahinejad, A., Attaran, A., Niyogi, S., Chivers, D.P. (2020) Rapid effects of estradiol and its receptors on object recognition and object placement in adult male zebrafish. Behavioural brain research. 384:112514
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