Gene

jag2b

ID

ZDB-GENE-011128-3

Name

jagged canonical Notch ligand 2b

Symbol

jag2b Nomenclature History

Previous Names

jag2
jagged2
serB
serrateB
unp1068
zgc:152855

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Is predicted to enable Notch binding activity and calcium ion binding activity. Involved in establishment or maintenance of epithelial cell apical/basal polarity and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Acts upstream of or within animal organ development. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of protein-containing complex. Is expressed in several structures, including anterior neural rod; digestive system; mesoderm; nervous system; and trunk. Orthologous to human JAG2 (jagged canonical Notch ligand 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

41 figures from 28 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu1049 (17 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With jag2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Muscular dystrophy, limb-girdle, autosomal recessive 27	619566

Associated With jag2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001007	VWFC domain
Domain	IPR001774	Delta/Serrate/lag-2 (DSL) protein
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR011651	Notch ligand, N-terminal domain
Family	IPR026219	Jagged/Serrate protein
Family	IPR033108	Protein jagged-1
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site

Domain Details Per Protein

Protein	Length	Delta/Serrate/lag-2 (DSL) protein	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	Growth factor receptor cysteine-rich domain superfamily	Jagged/Serrate protein	Notch ligand, N-terminal domain	Protein jagged-1	VWFC domain
UniProtKB:Q90Y56 InterPro	1254
UniProtKB:Q9YHU2 InterPro	1254
UniProtKB:Q5TZK7 InterPro	1216
UniProtKB:A0A2R8QT22 InterPro	1216
UniProtKB:Q0P4F9 InterPro	139
UniProtKB:A0A0R4IAF3 InterPro	1254
UniProtKB:B3DKL2 InterPro	1254
UniProtKB:Q90Y55 InterPro	1216
UniProtKB:Q5TZK8 InterPro	1254

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	jag2b-201 (1) Ensembl	5438 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	jag2b-202 (1) Ensembl	5324 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	jag2b-003 (1) Ensembl	812 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations