Gene
jag2b
- ID
- ZDB-GENE-011128-3
- Name
- jagged canonical Notch ligand 2b
- Symbol
- jag2b Nomenclature History
- Previous Names
-
- jag2
- jagged2
- serB
- serrateB
- unp1068
- zgc:152855
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Is predicted to enable Notch binding activity and calcium ion binding activity. Involved in establishment or maintenance of epithelial cell apical/basal polarity and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Acts upstream of or within animal organ development. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of protein-containing complex. Is expressed in several structures, including anterior neural rod; digestive system; mesoderm; nervous system; and trunk. Orthologous to human JAG2 (jagged canonical Notch ligand 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 41 figures from 28 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1049 (17 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Muscular dystrophy, limb-girdle, autosomal recessive 27 | 619566 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
Domain | IPR000742 | EGF-like domain |
Domain | IPR001007 | VWFC domain |
Domain | IPR001774 | Delta/Serrate/lag-2 (DSL) protein |
Domain | IPR001881 | EGF-like calcium-binding domain |
Domain | IPR011651 | Notch ligand, N-terminal domain |
Family | IPR026219 | Jagged/Serrate protein |
Family | IPR033108 | Protein jagged-1 |
Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
Protein | Length | Delta/Serrate/lag-2 (DSL) protein | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Jagged/Serrate protein | Notch ligand, N-terminal domain | Protein jagged-1 | VWFC domain |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q90Y56
|
1254 | ||||||||||
UniProtKB:Q9YHU2
|
1254 | ||||||||||
UniProtKB:Q5TZK7
|
1216 | ||||||||||
UniProtKB:A0A2R8QT22
|
1216 | ||||||||||
UniProtKB:Q0P4F9
|
139 | ||||||||||
UniProtKB:A0A0R4IAF3
|
1254 | ||||||||||
UniProtKB:B3DKL2
|
1254 | ||||||||||
UniProtKB:Q90Y55
|
1216 | ||||||||||
UniProtKB:Q5TZK8
|
1254 |
Interactions and Pathways
Plasmids
No data available