Gene
hsf2
- ID
- ZDB-GENE-011128-1
- Name
- heat shock transcription factor 2
- Symbol
- hsf2 Nomenclature History
- Previous Names
-
- zfHSF2
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables sequence-specific DNA binding activity. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in eye; hindbrain; and otic vesicle. Orthologous to human HSF2 (heat shock transcription factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa37125 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000232 | Heat shock factor (HSF)-type, DNA-binding |
Domain | IPR010542 | Vertebrate heat shock transcription factor, C-terminal domain |
Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Heat shock factor (HSF)-type, DNA-binding | Vertebrate heat shock transcription factor, C-terminal domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
---|---|---|---|---|---|---|
UniProtKB:Q90XA8 | InterPro | 489 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-150H13 | ||
Encodes | cDNA | MGC:77571 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131867 (1) | 2054 nt | ||
Genomic | GenBank:AL845365 (1) | 212942 nt | ||
Polypeptide | UniProtKB:Q90XA8 (1) | 489 aa |
- Shi, W.J., Long, X.B., Li, S.Y., Ma, D.D., Liu, F., Zhang, J.G., Lu, Z.J., Ying, G.G. (2022) Dydrogesterone and levonorgestrel at environmentally relevant concentrations have antagonist effects with rhythmic oscillation in brain and eyes of zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 248:106177
- Ruggiero, G., Ben-Moshe Livne, Z., Wexler, Y., Geyer, N., Vallone, D., Gothilf, Y., Foulkes, N.S. (2021) Period 2: A Regulator of Multiple Tissue-Specific Circadian Functions. Frontiers in molecular neuroscience. 14:718387
- Boswell, M., Boswell, W., Lu, Y., Savage, M., Walter, R.B. (2020) Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Scientific Reports. 10:3321
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Gong, L., Zhang, Q., Pan, X., Chen, S., Yang, L., Liu, B., Yang, W., Yu, L., Xiao, Z.X., Feng, X.H., Wang, H., Yuan, Z.M., Peng, J., Tan, W.Q., Chen, J. (2019) p53 Protects Cells from Death at the Heatstroke Threshold Temperature. Cell Reports. 29:3693-3707.e5
- Wang, C.C., Si, L.F., Guo, S.N., Zheng, J.L. (2019) Negative effects of acute cadmium on stress defense, immunity, and metal homeostasis in liver of zebrafish: The protective role of environmental zinc dpre-exposure. Chemosphere. 222:91-97
- Park, J., Belden, W.J. (2018) Long non-coding RNAs have age-dependent diurnal expression that coincides with age-related changes in genome-wide facultative heterochromatin. BMC Genomics. 19:777
- Si, L.F., Wang, C.C., Guo, S.N., Zheng, J.L., Xia, H. (2018) The lagged effects of environmentally relevant zinc on non-specific immunity in zebrafish. Chemosphere. 214:85-93
- Fei, F., Sun, S.Y., Yao, Y.X., Wang, X. (2017) [Generation and phenotype analysis of zebrafish mutations of obesity-related genes lepr and mc4r]. Sheng li xue bao : [Acta physiologica Sinica]. 69:61-69
- Zhao, S.J., Guo, S.N., Zhu, Q.L., Yuan, S.S., Zheng, J.L. (2017) Heat-induced oxidative stress and inflammation involve in cadmium pollution history in the spleen of zebrafish. Fish & shellfish immunology. 72:1-8
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