ZFIN is now using GRCz12tu for Genomic Data
Gene
dcc
- ID
- ZDB-GENE-011101-2
- Name
- DCC netrin 1 receptor
- Symbol
- dcc Nomenclature History
- Previous Names
-
- spaced out
- spo
- zdcc (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables netrin receptor activity involved in chemoattraction. Acts upstream of or within neuron differentiation and regulation of axon extension. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Is expressed in several structures, including brain; neural tube; pleuroperitoneal region; posterior neural rod; and primary motor neurons. Human ortholog(s) of this gene implicated in colorectal cancer; esophagus squamous cell carcinoma; and mirror movements 1. Orthologous to human DCC (DCC netrin 1 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 20 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| esophageal cancer | Alliance | Esophageal carcinoma, somatic | 133239 |
| mirror movements 1 | Alliance | Mirror movements 1 and/or agenesis of the corpus callosum | 157600 |
| Gaze palsy, familial horizontal, with progressive scoliosis, 2 | 617542 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR010560 | Neogenin, C-terminal |
| Domain | IPR013098 | Immunoglobulin I-set |
| Family | IPR009138 | Neural cell adhesion |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Neogenin, C-terminal | Neural cell adhesion |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0G2KXQ3 | InterPro | 757 | ||||||||||
| UniProtKB:Q49BB0 | InterPro | 1421 | ||||||||||
| UniProtKB:A0AC58JKH6 | InterPro | 1324 | ||||||||||
| UniProtKB:A0AC58JKH7 | InterPro | 1346 | ||||||||||
| UniProtKB:A0AC58JKH8 | InterPro | 1410 | ||||||||||
| UniProtKB:A0AC58JKH9 | InterPro | 1313 | ||||||||||
| UniProtKB:A0AC58JKI0 | InterPro | 1445 | ||||||||||
| UniProtKB:A0AC58JKI1 | InterPro | 1443 | ||||||||||
| UniProtKB:A0AC58JKI4 | InterPro | 1313 | ||||||||||
| UniProtKB:A0AC58JKI9 | InterPro | 1467 | ||||||||||
| UniProtKB:A0AC58JKK2 | InterPro | 727 | ||||||||||
| UniProtKB:A0AC58JKL6 | InterPro | 1324 | ||||||||||
| UniProtKB:A0AC58JKM7 | InterPro | 749 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers