ZFIN is now using GRCz12tu for Genomic Data
Gene
dcc
- ID
- ZDB-GENE-011101-2
- Name
- DCC netrin 1 receptor
- Symbol
- dcc Nomenclature History
- Previous Names
-
- spaced out
- spo
- zdcc (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables netrin receptor activity involved in chemoattraction. Acts upstream of or within with a positive effect on commissural neuron axon guidance. Acts upstream of or within neuron fate specification; neuron projection development; and regulation of axon extension. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Is expressed in several structures, including brain; neural tube; pleuroperitoneal region; posterior neural rod; and primary motor neurons. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 20 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| esophageal cancer | Alliance | Esophageal carcinoma, somatic | 133239 |
| mirror movements 1 | Alliance | Mirror movements 1 and/or agenesis of the corpus callosum | 157600 |
| Gaze palsy, familial horizontal, with progressive scoliosis, 2 | 617542 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR010560 | Neogenin, C-terminal |
| Domain | IPR013098 | Immunoglobulin I-set |
| Family | IPR009138 | Neural cell adhesion |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Neogenin, C-terminal | Neural cell adhesion |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0G2KXQ3 | InterPro | 757 | ||||||||||
| UniProtKB:Q49BB0 | InterPro | 1421 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers