neurog3

ID

ZDB-GENE-010608-4

Name

neurogenin 3

Symbol

neurog3 Nomenclature History

Previous Names

atoh4
ngn2 (1)
ngn3 (1)
ngn3a (1)
Zath4b (1)

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Predicted to be involved in nervous system development; positive regulation of transcription by RNA polymerase II; and sensory organ development. Predicted to act upstream of or within cell differentiation and nervous system development. Predicted to be active in nucleus. Is expressed in endocrine pancreas; gut; and hypothalamus. Human ortholog(s) of this gene implicated in congenital malabsorptive diarrhea 4; glucose intolerance; and type 2 diabetes mellitus. Orthologous to human NEUROG3 (neurogenin 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With neurog3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital malabsorptive diarrhea 4	Alliance	Diarrhea 4, malabsorptive, congenital	610370

Associated With neurog3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Domain	IPR032656	Neurogenin-3, basic helix-loop-helix domain
Family	IPR050359	Basic helix-loop-helix transcription factors
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily