Gene

dhfr

ID
ZDB-GENE-010406-5
Name
dihydrofolate reductase
Symbol
dhfr Nomenclature History
Previous Names
  • cb595 (1)
  • zgc:86637
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Enables dihydrofolate reductase activity. Involved in dihydrofolate metabolic process and tetrahydrofolate biosynthetic process. Acts upstream of or within folic acid metabolic process; heart contraction; and heart development. Is expressed in several structures, including anterior neural tube; hematopoietic system; immature eye; nervous system; and neural plate. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human DHFR (dihydrofolate reductase) and DHFR2 (dihydrofolate reductase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dhfr Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
megaloblastic anemia Alliance Megaloblastic anemia due to dihydrofolate reductase deficiency 613839
Associated With dhfr Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001796 Dihydrofolate reductase domain
Family IPR012259 Dihydrofolate reductase
Homologous_superfamily IPR024072 Dihydrofolate reductase-like domain superfamily
Domain Details Per Protein
Protein Length Dihydrofolate reductase Dihydrofolate reductase domain Dihydrofolate reductase-like domain superfamily
UniProtKB:Q98TR9 191
UniProtKB:Q6IQS4 190
UniProtKB:A2BGQ1 190
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations