ZFIN is now using GRCz12tu for Genomic Data
Gene
or70a12
- ID
- ZDB-GENE-010309-2
- Name
- odorant receptor, family 70, subfamily A, member 12
- Symbol
- or70a12 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be active in membrane. Is expressed in olfactory epithelium. Orthologous to several human genes including OR4M2 (olfactory receptor family 4 subfamily M member 2) and OR4M2B (olfactory receptor family 4 subfamily M member 2B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Jundi et al., 2023
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G-protein Coupled Receptor 1 Superfamily Member | G protein-coupled receptor, rhodopsin-like | Olfactory receptor |
|---|---|---|---|---|---|---|
| UniProtKB:Q2PRH6 | InterPro | 308 | ||||
| UniProtKB:Q9DFC7 | InterPro | 312 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
or115-1-201
(1)
|
Ensembl | 1,586 nt | ||
| mRNA |
or115-1-202
(1)
|
Ensembl | 1,641 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-218M3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193995 | ZFIN Curated Data |
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- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131742 (1) | 1626 nt | ||
| Genomic | GenBank:CU104696 (1) | 163593 nt | ||
| Polypeptide | UniProtKB:Q9DFC7 (1) | 312 aa |
No data available
- Jundi, D., Coutanceau, J.P., Bullier, E., Imarraine, S., Fajloun, Z., Hong, E. (2023) Expression of olfactory receptor genes in non-olfactory tissues in the developing and adult zebrafish. Scientific Reports. 13:46514651
- Olender, T., Jones, T.E.M., Bruford, E., Lancet, D. (2020) A unified nomenclature for vertebrate olfactory receptors. BMC Evolutionary Biology. 20:42
- Saraiva, L.R., Ahuja, G., Ivandic, I., Syed, A.S., Marioni, J.C., Korsching, S.I., Logan, D.W. (2015) Molecular and neuronal homology between the olfactory systems of zebrafish and mouse. Scientific Reports. 5:11487
- Niimura, Y. (2009) On the Origin and Evolution of Vertebrate Olfactory Receptor Genes: Comparative Genome Analysis Among 23 Chordate Species. Genome biology and evolution. 1:34-44
- Alioto, T.S., and Ngai, J. (2005) The odorant receptor repertoire of teleost fish. BMC Genomics. 6:173
- Niimura, Y., and Nei, M. (2005) Evolutionary dynamics of olfactory receptor genes in fishes and tetrapods. Proceedings of the National Academy of Sciences of the United States of America. 102(17):6039-6044
- Irie-Kushiyama, S., Asano-Miyoshi, M., Suda, T., Abe, K., and Emori, Y. (2004) Identification of 24 genes and two pseudogenes coding for olfactory receptors in Japanese loach, classified into four subfamilies: a putative evolutionary process for fish olfactory receptor genes by comprehensive phylogenetic analysis. Gene. 325:123-135
- Kratz, E., Dugas, J.C., and Ngai, J. (2002) Odorant receptor gene regulation: implications from genomic organization. Trends in genetics : TIG. 18(1):29-34
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
- Dugas, J.C. and Ngai, J. (2001) Analysis and characterization of an odorant receptor gene cluster in the zebrafish genome. Genomics. 71(1):53-65
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